Results 71 to 80 of about 2,988,254 (363)

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

FEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi, Takehiro Suzuki, Ryota Kawahara, Natsumi Harai, Naoshi Dohmae, Siro Simizu   +5 more
wiley   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

Efimov Physics around the neutron rich Calcium-60 isotope [PDF]

, 2013
We calculate the neutron-Calcium-60 S-wave scattering phase shifts using state of the art coupled-cluster theory combined with modern ab initio interactions derived from chiral effective theory.
Hagen, G., Hagen, P., Hammer, H. -W., Platter, L.   +3 more
core   +2 more sources

Single cis‐elements in brassinosteroid‐induced upregulated genes are insufficient to recruit both redox states of the BIL1/BZR1 DNA‐binding domain

FEBS Letters, EarlyView.
Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki, Masae Ohtsuka, Takeshi Nakano, Masaru Tanokura, Takuya Miyakawa   +4 more
wiley   +1 more source

Regulation of Neutrophil Degranulation and Cytokine Secretion: A Novel Model Approach Based on Linear Fitting

Journal of Immunology Research, 2015
Neutrophils participate in the maintenance of host integrity by releasing various cytotoxic proteins during degranulation. Due to recent advances, a major role has been attributed to neutrophil-derived cytokine secretion in the initiation, exacerbation ...
Isabelle Naegelen, Nicolas Beaume, Sébastien Plançon, Véronique Schenten, Eric J. Tschirhart, Sabrina Bréchard   +5 more
doaj   +1 more source

Mild-intensity physical activity prevents cardiac and osseous iron deposition without affecting bone mechanical property or porosity in thalassemic mice

Scientific Reports, 2022
Thalassemia causes anemia, ineffective erythropoiesis, bone loss and iron accumulation in several tissues, e.g., liver, bone and heart, the last of which leads to lethal cardiomyopathy and arrhythmia. Although exercise reportedly improves bone density in
Narattaphol Charoenphandhu, Supagarn Sooksawanwit, Ratchaneevan Aeimlapa, Natchayaporn Thonapan, Pornpailin Upanan, Punyanuch Adulyaritthikul, Saowalak Krungchanuchat, Nattapon Panupinthu, Jarinthorn Teerapornpuntakit, Catleya Rojviriya, Kornkamon Lertsuwan, Saovaros Svasti, Kannikar Wongdee   +12 more
doaj   +1 more source

Use of chicken eggshell to improve dietary calcium intake in rural sub-Saharan Africa [PDF]

, 2018
Undernutrition resulting from inadequate access to high‐quality, nutritious food is a widespread issue in sub‐Saharan Africa impacting the health and survival of mothers and their children.
Akins, Alao, Alders, Bagnol, Bhutta, Black, Boulkedid, Braun, Brun, Darnton-Hill, Dowling, Feasey, Fusch, Gantois, Guèye, Helgason, Hofmeyr, Humphries, Kulwa, Liu, Mann, Marks, Mayes, Messens, Mierlo, Milbradt, Naves, Omotayo, Rice, Richards, Rovenský, Rowe, Schaafsma, Schaafsma, Sheikh, Thacher, Vaclavik, Wentholt, Whiley, Willey, World Health Organization, Zerfu   +41 more
core   +2 more sources

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

FEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke, Nils Alexander Lakomek, Georg Groth   +2 more
wiley   +1 more source

Dendritic spine geometry and spine apparatus organization govern the spatiotemporal dynamics of calcium. [PDF]

, 2019
Dendritic spines are small subcompartments that protrude from the dendrites of neurons and are important for signaling activity and synaptic communication. These subcompartments have been characterized to have different shapes.
Bartol, Tom, Bell, Miriam, Rangamani, Padmini, Sejnowski, Terrence   +3 more
core  

Disruption of Vitamin D and Calcium Signaling in Keratinocytes Predisposes to Skin Cancer. [PDF]

, 2016
1,25 dihydroxyvitamin D (1,25(OH)2D), the active metabolite of vitamin D, and calcium regulate epidermal differentiation. 1,25(OH)2D exerts its effects through the vitamin D receptor (VDR), a transcription factor in the nuclear hormone receptor family ...
Bikle, Daniel D, Jiang, Yan, Nguyen, Thai, Oda, Yuko, Tu, Chia-Ling   +4 more
core   +2 more sources