Results 71 to 80 of about 3,765,678 (388)
Arrhythmogenesis in Timothy Syndrome is associated with defects in Ca2+-dependent inactivation
Nature Communications, 2016 Timothy Syndrome (TS) is a multisystem disorder caused by two mutations leading to dysfunction of the CaV1.2 channel. Here, Dick et al. uncover a major and mechanistically divergent effect of both mutations on Ca2+/calmodulin-dependent inactivation of ...
Ivy E. Dick +3 more
doaj +1 more source
Vascular Calcification and Stone Disease: A New Look towards the Mechanism
Journal of Cardiovascular Development and Disease, 2015 Calcium phosphate (CaP) crystals are formed in pathological calcification as well as during stone formation. Although there are several theories as to how these crystals can develop through the combined interactions of biochemical and biophysical factors,
Allen J. Yiu +3 more
doaj +1 more source
Calcium and Excitation-Contraction Coupling in the Heart
Circulation Research, 2017 Cardiac contractility is regulated by changes in intracellular Ca concentration ([Ca2+]i). Normal function requires that [Ca2+]i be sufficiently high in systole and low in diastole.
D. Eisner +3 more
semanticscholar +1 more source
The Activity of Calcium in Calcium-Calcium Halide Fluxes.
ISIJ International, 1996 The activities of calcium in the CaOsatd.-Ca-CaX2 fluxes (X: Cl, Br, I) were measured as a function of the calcium composition at 1 473 K by equilibrating these fluxes with a solid zirconium plate. The activities decreased in the order CaCl2, Cal2 and CaBr2 at the same calcium fraction of these fluxes.
Ken-ichi Mori +4 more
openaire +3 more sources
FEBS Letters, EarlyView.The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp +5 more
wiley +1 more source
Journal of Orthopedic and Spine Trauma, 2016 Introduction: Bone cement leakage is the most common, however, it can have potentially disastrous complications during vertebroplasty and balloon kyphoplasty (BK).
Papaioannou Ioannis +2 more
doaj +1 more source
Annals of Botany, 2003 Calcium is an essential plant nutrient. It is required for various structural roles in the cell wall and membranes, it is a counter-cation for inorganic and organic anions in the vacuole, and the cytosolic Ca2+ concentration ([Ca2+]cyt) is an obligate ...
P. White, M. Broadley
semanticscholar +1 more source
FEBS Letters, EarlyView.UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg +2 more
wiley +1 more source
Development and in vitro characterization of humanized antibodies for blocking human TRPM4 channel
Scientific ReportsTransient receptor potential melastatin 4 (TRPM4) channel, a monovalent cation channel, plays a crucial role in various neurological disorders. We previously showed that TRPM4 activity can be blocked by our antibodies: M4P, which targets rat TRPM4 and ...
Shunhui Wei +6 more
doaj +1 more source
Caged calcium in Aplysia pacemaker neurons. Characterization of calcium-activated potassium and nonspecific cation currents. [PDF]
, 1989 We have studied calcium-activated potassium current, IK(Ca), and calcium-activated nonspecific cation current, INS(Ca), in Aplysia bursting pacemaker neurons, using photolysis of a calcium chelator (nitr-5 or nitr-7) to release caged calcium ...
Landò, L, ZUCKER, Robert S.
core +2 more sources