Results 71 to 80 of about 3,058,950 (364)

Dendritic spine geometry and spine apparatus organization govern the spatiotemporal dynamics of calcium. [PDF]

, 2019
Dendritic spines are small subcompartments that protrude from the dendrites of neurons and are important for signaling activity and synaptic communication. These subcompartments have been characterized to have different shapes.
Bartol, Tom, Bell, Miriam, Rangamani, Padmini, Sejnowski, Terrence   +3 more
core  

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Calcium and magnesium absorption and retention by growing goats offered diets with different calcium sources [PDF]

, 2016
Calcium addition is necessary in order to balance the high phosphorus concentrations that are characteristic of high-concentrate ruminant diets. However, calcium sources differ in their bioavailability. Our objective was to determine apparent calcium and
Caldwell, James D., Coffey, Kenneth P., Long, Jennifer E., Philipp, Dirk, Rhein, Robert T., Young, Ashley N.   +5 more
core   +2 more sources

ER-Mitochondria contact sites : a new regulator of cellular calcium flux comes into play [PDF]

, 2016
Endoplasmic reticulum (ER)-mitochondria membrane contacts are hotspots for calcium signaling. In this issue, Raturi et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201512077) show that the thioredoxin TMX1 inhibits the calcium pump SERCA2b at ...
Anelli, Appenzeller-Herzog, Bittremieux, Booth, Csordás, Cárdenas, Cárdenas, Doghman-Bouguerra, Geert Bultynck, Hayashi, Higo, Krols, Li, Lynes, Lynes, Marchi, Marino, Michiel Krols, Raturi, Rizzuto, Roderick, Sophie Janssens, Szabadkai   +22 more
core   +2 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Diagnostic analysis of RO desalting treated waste water [PDF]

, 2008
Diagnostic analysis of reverse osmosis membranes that were fed with Western treatment plant (WTP) recycled water was investigated by both thermodynamic calculations and laboratory experiments in order to predict the feasibility of RO desalting for WTP.
Cohen, Yoram, Gray, Stephen, Rahardianto, A, Semiat, R, Wilson, S, Zach-Maor, A   +5 more
core  

Use of chicken eggshell to improve dietary calcium intake in rural sub-Saharan Africa [PDF]

, 2018
Undernutrition resulting from inadequate access to high‐quality, nutritious food is a widespread issue in sub‐Saharan Africa impacting the health and survival of mothers and their children.
Akins, Alao, Alders, Bagnol, Bhutta, Black, Boulkedid, Braun, Brun, Darnton-Hill, Dowling, Feasey, Fusch, Gantois, Guèye, Helgason, Hofmeyr, Humphries, Kulwa, Liu, Mann, Marks, Mayes, Messens, Mierlo, Milbradt, Naves, Omotayo, Rice, Richards, Rovenský, Rowe, Schaafsma, Schaafsma, Sheikh, Thacher, Vaclavik, Wentholt, Whiley, Willey, World Health Organization, Zerfu   +41 more
core   +2 more sources

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Regulation of Neutrophil Degranulation and Cytokine Secretion: A Novel Model Approach Based on Linear Fitting

Journal of Immunology Research, 2015
Neutrophils participate in the maintenance of host integrity by releasing various cytotoxic proteins during degranulation. Due to recent advances, a major role has been attributed to neutrophil-derived cytokine secretion in the initiation, exacerbation ...
Isabelle Naegelen, Nicolas Beaume, Sébastien Plançon, Véronique Schenten, Eric J. Tschirhart, Sabrina Bréchard   +5 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source