Results 81 to 90 of about 3,765,678 (388)

ER-Mitochondria contact sites : a new regulator of cellular calcium flux comes into play [PDF]

, 2016
Endoplasmic reticulum (ER)-mitochondria membrane contacts are hotspots for calcium signaling. In this issue, Raturi et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201512077) show that the thioredoxin TMX1 inhibits the calcium pump SERCA2b at ...
Anelli, Appenzeller-Herzog, Bittremieux, Booth, Csordás, Cárdenas, Cárdenas, Doghman-Bouguerra, Geert Bultynck, Hayashi, Higo, Krols, Li, Lynes, Lynes, Marchi, Marino, Michiel Krols, Raturi, Rizzuto, Roderick, Sophie Janssens, Szabadkai   +22 more
core   +2 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Detecting stoichiometry of macromolecular complexes in live cells using FRET

Nature Communications, 2016
Measuring thein vivo stoichiometry of protein-protein interactions is challenging. Here the authors take a FRET-based approach, quantifying stoichiometry based on ratiometric comparison of donor and acceptor fluorescence, and apply their method to report
Manu Ben-Johny, Daniel N. Yue, David T. Yue   +2 more
doaj   +1 more source

Transcriptional regulation by calcium, calcineurin, and NFAT.

Genes & Development, 2003
The NFAT family of transcription factors encompasses five proteins evolutionarily related to the Rel/NF B family (Chytil and Verdine 1996; Graef et al. 2001b).
P. Hogan, Lin Chen, J. Nardone, A. Rao
semanticscholar   +1 more source

Impact of calcium on salivary α-amylase activity, starch paste apparent viscosity and thickness perception [PDF]

, 2011
Thickness perception of starch-thickened products during eating has been linked to starch viscosity and salivary amylase activity. Calcium is an essential cofactor for α-amylase and there is anecdotal evidence that adding extra calcium affects ...
A Kumari, AAD Comrie, AC Alting, AD Nielsen, AL Ferry, ALS Ferry, Andrew J. Taylor, AR Nazmi, BL Vallee, Cecile Morris, CF Gonzalez, CI Heinzerling, D Suvd, DS Bush, E Bertoft, E Salvolini, G Muralikrishna, ID Evans, J Hsiu, J Kivela, J Lin, JGL Harrison, JW Woolnough, L Engelen, L Sewon, LS Collado, M Machius, M O’Mahony, M Tietz, MJ Larsen, RA Wijk de, RG Schipper, Susanne L. Fichtel, WM Edgar   +33 more
core   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Hypercalciuria switches Ca2+ signaling in proximal tubular cells, induces oxidative damage to promote calcium nephrolithiasis

Genes and Diseases, 2022
Proximal tubule (PT) transports most of the renal Ca2+, which was usually described as paracellular (passive). We found a regulated Ca2+ entry pathway in PT cells via the apical transient receptor potential canonical 3 (TRPC3) channel, which initiates ...
Samuel Shin, Cliff-Lawrence Ibeh, Eugenia Awuah Boadi, Bok-Eum Choi, Sanjit K. Roy, Bidhan C. Bandyopadhyay   +5 more
doaj  

Dendritic spike induction of postsynaptic cerebellar LTP [PDF]

, 2008
The architecture of parallel fiber (PF) axons contacting cerebellar Purkinje neurons (PNs) retains spatial information over long distances. PF synapses can trigger local dendritic calcium spikes, but whether and how this calcium signal leads to plastic ...
Kaspar E. Vogt, Marco Canepari
core   +1 more source

Oxytocin at physiological concentrations evokes adrenocorticotropin (ACTH) release from corticotrophs by increasing intracellular free calcium mobilized mainly from intracellular stores. Oxytocin displays synergistic or additive effects on ACTH-releasing factor or arginine vasopressin-induced ACTH secretion, respectively [PDF]

, 1992
The potency of oxytocin (OT) in evoking ACTH secretion by isolated, superfused rat adenohypophyseal corticotrophs and its enhancement by CRF and arginine vasopressin (AVP) were analyzed.
Dayanithi, G., Föhr, K. J., Gratzl, Manfred, Link, H.   +3 more
core   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source