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Calcium channels in hepatocytes
Journal of Hepatology, 1988In living cells, the concentration of cytosolic Ca :+ ([Ca2+]i) is maintained at a level ranging from 50 to 200 nM. The cytosolic Ca 2+ is actively extruded from the cell by a Ca2+-pump present in the plasma membrane and/or by Ca2+/Na + exchange. In resting cells, Ca 2+ is accumulated essentially in the endoplasmic ' reticulum and, to a lesser extent ...
J P, Mauger, M, Claret
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Current Opinion in Nephrology and Hypertension, 1994
A key step in renal calcium reabsorption is dihydropyridine-sensitive calcium entry across the apical membrane of the distal tubule. Electrophysiologic studies have confirmed the existence of calcium channels that may mediate this pathway. Molecular studies of voltage-dependent calcium channels have revealed a surprising degree of heterogeneity.
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A key step in renal calcium reabsorption is dihydropyridine-sensitive calcium entry across the apical membrane of the distal tubule. Electrophysiologic studies have confirmed the existence of calcium channels that may mediate this pathway. Molecular studies of voltage-dependent calcium channels have revealed a surprising degree of heterogeneity.
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Annual Review of Pharmacology and Toxicology, 1987
The Ca2+ channel blockers, diltiazem, nifedipine, and vcrapamil, are now well-established members of the therapeutic armamentarium employed in cardiovascular disease including, but not limited to, angina in its several forms, hypertension, some cardiac arrhythmias including supraventricular tachycardia, congestive heart failure, and hypertrophic ...
D J, Triggle, R A, Janis
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The Ca2+ channel blockers, diltiazem, nifedipine, and vcrapamil, are now well-established members of the therapeutic armamentarium employed in cardiovascular disease including, but not limited to, angina in its several forms, hypertension, some cardiac arrhythmias including supraventricular tachycardia, congestive heart failure, and hypertrophic ...
D J, Triggle, R A, Janis
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Calcium channel blockers and calcium channels
2004In 1883, Ringer showed that to get isolated hearts to contract, it was necessary to have Ca2+ ions in the perfusion medium [421]. This was the first demonstration of the critical role of calcium in cellular activity. Remarkably, a hundred years passed before the importance of calcium was recognized in processes other than muscle contraction, and almost
Eric Ertel, Théophile Godfraind
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Science, 2016
Structural Biology The type 2 ryanodine receptor (RyR2) controls the release of calcium ions from the sarcoplasmic reticulum in cardiac cells—the initiating step in cardiac muscle contraction. Mutations in RyR2 are associated with cardiac diseases. Peng et al.
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Structural Biology The type 2 ryanodine receptor (RyR2) controls the release of calcium ions from the sarcoplasmic reticulum in cardiac cells—the initiating step in cardiac muscle contraction. Mutations in RyR2 are associated with cardiac diseases. Peng et al.
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Calcium channel modulators and calcium channels.
Biochemical Society symposium, 1986In recent years calcium has become recognized as an important 'second messenger', in that an increase in free intracellular calcium ion concentration is involved in many aspects of cellular activation. In excitable cells such as smooth muscle or cardiac tissue an influx of extracellular calcium ions through voltage sensitive calcium channels plays a ...
R, Towart, M, Schramm
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AACN Advanced Critical Care, 1992
Calcium channel blockers are widely used in the treatment of ischemic heart disease, hypertension, and supraventricular tachycardia. The prototype agents, verapamil, nifedipine, and diltiazem, represent three classes of calcium channel blockers, each of which has different pharmacologic effects.
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Calcium channel blockers are widely used in the treatment of ischemic heart disease, hypertension, and supraventricular tachycardia. The prototype agents, verapamil, nifedipine, and diltiazem, represent three classes of calcium channel blockers, each of which has different pharmacologic effects.
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Calcium channel activation stabilizes a neuronal calcium channel mRNA
Nature Neuroscience, 1999We have identified a calcium-dependent pathway in neurons that regulates expression levels of the alpha1B subunit and N channel current. When neurons are depolarized and voltage-gated calcium channels activated, the half-life of cellular N channel alpha1B mRNA is prolonged.
S, Schorge +4 more
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Inactivation of calcium channels
Comparative Biochemistry and Physiology Part A: Physiology, 1989Rapid progress in our understanding of the properties and functions of voltage-gated calcium channels had produced the need for an update to our previous review of calcium inactivation. The major elements of change included in this review are: 1.
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Calcium channel diversity: multiple roles of calcium channel subunits
Current Opinion in Neurobiology, 2009Until recently we held the simple view that voltage-gated calcium channels consisted of an alpha1 subunit, usually associated with auxiliary beta subunits and alpha(2)delta subunits and that skeletal muscle calcium channels were also associated with a gamma subunit.
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