Blocker effect on diffusion resistance of a membrane channel. Dependence on the blocker geometry [PDF]
Being motivated by recent progress in nanopore sensing, we develop a theory of the effect of large analytes, or blockers, trapped within the nanopore confines, on diffusion flow of small solutes. The focus is on the nanopore diffusion resistance which is the ratio of the solute concentration difference in the reservoirs connected by the nanopore to the
arxiv
Effects of combination of statin and calcium channel blocker in patients with cardiac syndrome X
ObjectivesStatins and calcium channel blockers have been proven beneficial toward improvement of endothelial function. The aim of this study was to compare the effect of combination therapy of statin and calcium channel blocker with solo treatment in ...
Xinling Zhang+7 more
semanticscholar +1 more source
Bilateral blindness secondary to optic nerve ischemia from severe amlodipine overdose: a case report
Background Calcium channel blockers are commonly prescribed medications; calcium channel blocker overdose is becoming increasingly prevalent. The typical presentation of a calcium channel blocker overdose is hypotension and decreased level of ...
Raymond Kao+3 more
doaj +1 more source
R-type calcium channels are crucial for semaphorin 3A-induced DRG axon growth cone collapse. [PDF]
Semaphorin 3A (Sema3A) is a secreted protein involved in axon path-finding during nervous system development. Calcium signaling plays an important role during axonal growth in response to different guidance cues; however it remains unclear whether this ...
Rimantas Treinys+4 more
doaj +1 more source
Calcium channel blockers (CCB) overdose can result in cardiogenic shock and that high dose insulin euglycaemic therapy (HIET) is increasingly used to treat CCB poisoning.
Andrew Kozman+2 more
doaj +1 more source
Identifying factors associated with fast visual field progression in patients with ocular hypertension based on unsupervised machine learning [PDF]
Purpose: To identify ocular hypertension (OHT) subtypes with different trends of visual field (VF) progression based on unsupervised machine learning and to discover factors associated with fast VF progression. Participants: A total of 3133 eyes of 1568 ocular hypertension treatment study (OHTS) participants with at least five follow-up VF tests were ...
arxiv
A functional role for small-conductance calcium-activated potassium channels in sensory pathways including nociceptive processes [PDF]
We investigated the role of small-conductance calcium-activated potassium (SK) and intermediate-conductance calcium-activated potassium channels in modulating sensory transmission from peripheral afferents into the rat spinal cord.
Bahia, PK+7 more
core +1 more source
We studied the effects of antihypertensive calcium channel blockers on CaV1.2, the predominantly expressed L‐type calcium channel in the largest human lymphatic vessel, the thoracic duct.
N. Telinius+10 more
semanticscholar +1 more source
The calcium channel blockers initially were approved for the treatment of classical and variant angina pectoris. Recent studies indicate that these agents also are useful in such diverse conditions as pulmonary and systemic hypertension, hypertrophic cardiomyopathy, arrhythmias, asthma, Raynaud's syndrome, esophageal spasm, myometrial hyperactivity ...
openaire +3 more sources
Mechanism of resveratrol-induced relaxation in the human gallbladder
Background Resveratrol is a polyphenolic compound extracted from plants and is also a constituent of red wine. Resveratrol produces relaxation of vascular smooth muscle and may prevent cardiovascular diseases.
Ching-Chung Tsai+4 more
doaj +1 more source