Results 21 to 30 of about 449,480 (336)

The risk of second primary malignancies in colorectal cancer patients using calcium channel blockers

Scientific Reports, 2023
Calcium channel blockers are among the most commonly used agents in the treatment of cardiovascular diseases. There are several known side-effects associated with their long-term use, whereas other potential adverse effects are yet to be proven.
Jana Halámková, Lucia Bohovicová, Lucie Pehalová, Tomáš Kazda, Roman Goněc, Teodor Staněk, Lucie Mouková, Dagmar Adámková Krákorová, Šárka Kozáková, Marek Svoboda, Regina Demlová, Lucie Gabrielová, Lenka Hernychová, Igor Kiss   +13 more
doaj   +1 more source

Calcium channel blockers

Medicine, 2003
Overdose of calcium channel blockers is potentially lethal. Verapamil and diltiazem are much more dangerous than dihydropyridines. Hypotension with (verapamil and diltiazem) or without (dihydropyridines) heart block and bradycardia are the most important features.
Buckley, Nicholas, Dawson, Andrew, Whyte, Ian M   +2 more
openaire   +2 more sources

Comparison of First-Line Dual Combination Treatments in Hypertension: Real-World Evidence from Multinational Heterogeneous Cohorts. [PDF]

, 2020
Background and objectives: 2018 ESC/ESH Hypertension guideline recommends 2-drug combination as initial anti-hypertensive therapy. However, real-world evidence for effectiveness of recommended regimens remains limited.
Cho, Jaehyeong, Hripcsak, George, Jung, Sungjae, Lee, Seongwon, Park, Rae Woong, Park, Sungha, Ryan, Patrick B, Schuemie, Martijn J, Suchard, Marc A, Swerdel, Joel N, You, Seng Chan   +10 more
core   +2 more sources

Protective Effect of Peptide Calcium Channel Blocker Omega-Hexatoxin-Hv1a on Epithelial Cell during Ischemia–Reperfusion Injury

Pharmaceuticals, 2023
Ischemia–reperfusion injury (IRI) is a common phenomenon that develops both from natural causes and during major operations. Many intracellular processes mediated by calcium ions are involved in the development of IRI. Currently, chemical calcium channel
Elena Iurova, Eugenia Rastorgueva, Evgenii Beloborodov, Evgeniya Pogodina, Aleksandr Fomin, Dmitrii Sugak, Denis Viktorov, Ivan Tumozov, Yury Saenko   +8 more
doaj   +1 more source

Voltage-gated calcium channel blockers for psychiatric disorders: genomic reappraisal

British Journal of Psychiatry, 2019
Summary We reappraise the psychiatric potential of calcium channel blockers (CCBs). First, voltage-gated calcium channels are risk genes for several disorders. Second, use of CCBs is associated with altered psychiatric risks and outcomes. Third, research
Paul J. Harrison, E. Tunbridge, A. Dolphin, J. Hall   +3 more
semanticscholar   +1 more source

Tissue-specific expression of calcium channels [PDF]

, 1993
The high-voltage-activated calcium channel is a multimeric protein complex containing 1, 2/δ, β, and γ subunits. The 1 subunit is the ion conduction channel and contains the binding sites for calcium channel blockers and toxins.
Biel, Biel, Bosse, Bosse, Catterall, Cavalié, Dascal, De Jongh, De Jongh, De Jongh, Diebold, Dubel, Ellis, Fleckenstein, Flockerzi, Glossmann, Guy, Hartzell, Heinemann, Hofmann, Hofmann, Hullin, Hymel, Jay, Jay, Kim, Kim, Klöckner, Lacerda, Mikami, Mintz, Mori, Mundiña-Weilenmann, Nakayama, Norman, Nunoki, Osterrieder, Perez-Reyes, Perez-Reyes, Pragnell, Regulla, Rotman, Ruth, Röhrkasten, Scino, Singer, Snutch, Striessnig, Striessnig, Tanabe, Tanabe, Tanabe, Tsien, Varadi, Wei, Welling, Welling, Williams, Williams, Yatani   +59 more
core   +1 more source

Chronic beta-adrenoceptor blockade and human atrial cell electrophysiology: evidence of pharmacological remodelling [PDF]

, 2003
<b>Objective:</b> Chronic beta-adrenoceptor antagonist (β-blocker) treatment reduces the incidence of reversion to AF in patients, possibly via an adaptive myocardial response.
Kane, K.A., Norrie, J., Rankin, A.C., Russell, J.A., Workman, A.J.   +4 more
core   +1 more source

T-type Ca2+ Channels: T for Targetable [PDF]

, 2018
In the last decade TTCC have been unveiled as key regulators of cancer cells biology and thus have been proposed as chemotherapeutic targets. Indeed in vitro and in vivo studies indicate that TTCC pharmacological blockers have a negative impact on the ...
Cantí Nicolás, Carles, Crespí Sallán, Marta, Herreros Danés, Judit, Nàger Grifo, Mireia, Shaikh, Soni, Visa Pretel, Anna   +5 more
core   +2 more sources

Prescription Patterns of Antihypertensive Drugs at Tertiary Care Hospital: A Descriptive Cross Sectional Study

Journal of Nobel Medical College, 2020
Background: Hypertension is leading cause of deaths in the world. It is a modifiable and major risk factor for cardiovascular, renal and brain diseases. This study was done to see the current trend of prescription patterns of antihypertensive drugs in a ...
Kamal Sharma Lamsal, Keshav Raj Neupane, Rajati Sharma Kafle   +2 more
doaj   +1 more source

Synergistic Effect of Fluconazole and Calcium Channel Blockers against Resistant Candida albicans

PLoS ONE, 2016
Candidiasis has increased significantly recently that threatens patients with low immunity. However, the number of antifungal drugs on the market is limited in comparison to the number of available antibacterial drugs.
Shuyuan Liu, L. Yue, Wenrui Gu, Xiuyun Li, Liuping Zhang, Shujuan Sun   +5 more
semanticscholar   +1 more source