Results 31 to 40 of about 91,887 (263)
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Calcium-channel blockers and anaesthesia [PDF]
Canadian Journal of Anaesthesia, 1991 Verapamil was the first calcium-channel blocker (CCB). It has been used since 1962 in Europe then in Japan for its antiarrhythmic and coronary vasodilator effects. The CCB have become prominent cardiovascular drugs during the last 15 years. Many experimental and clinical studies have defined their mechanism of action, the effects of new drugs in this ...
P G, Durand, J J, Lehot, P, Foëx
openaire +3 more sources
Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins
FEBS Open Bio, EarlyView.Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley +1 more source
Acta Dermato-VenereologicaTelangiectasia macularis multiplex acquisita is an acquired cutaneous telangiectasis of unknown aetiology, and it lacks both effective and cost-efficient treatment.
Tian Chen +6 more
doaj +1 more source
Gingival Enlargement in Antihypertensive Medication
Journal of Nepal Medical Association, 2009 Introduction: Drug-induced gingival enlargement is a well documented side effect with the use of phenytoin, cyclosporine and calcium channel blockers. The prevalence of gingival enlargement induced by calcium channel blockers is uncertain.
Shaili Pradhan, P Mishra
doaj +1 more source
Herbicidal properties of antihypertensive drugs: calcium channel blockers
Scientific Reports, 2021 Herbicide resistance is a worldwide problem in weed control. This prompts researchers to look for new modes of action to slow down the evolution of herbicide-resistant weeds.
Hannan Safiyyah Tan Sian Hui Abdullah +3 more
doaj +1 more source
Are calcium channel blockers related to lung cancer?
Drug Target Insights, 2023 Background: Calcium channel blocker (CCB) is a common antihypertensive agent for the treatment of hypertension. There are inconsistent data of an association of CCB and lung cancer in the literature.
Ratchanon Rattanathanoo +5 more
doaj +1 more source
Calcium Channel Blocker Overdose
Journal of education & teaching in emergency medicineEmergency medicine residents and medical students on emergency medicine rotation.Calcium channel blocker (CCB) overdoses can be severe with potentially serious adverse outcomes. CCBs work by blocking the calcium channels on smooth and cardiac muscle tissue. At low dose ranges, dihydropyridine CCBs (such as nifedipine, amlodipine, and nicardipine) block
Andrusaitis, MD, MS, Jessica G. +1 more
openaire +3 more sources
Calcium channel blockers‐are they diuretics? [PDF]
British Journal of Clinical Pharmacology, 1985 Seven untreated patients with essential hypertension but without target organ damage were admitted to hospital. Urine was collected the following day from 08.00 to 13.00 h, 13.00 to 18.00 h, and 18.00 to 08.00 h. The protocol was repeated the next day following 30 mg oral nicardipine.
M A, Young +3 more
openaire +2 more sources
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source