Results 41 to 50 of about 88,833 (259)

Comparison between The Effect of Progesterone and Calcium Channel blockers in Control of Threatened Preterm Labor [PDF]

Al-Azhar International Medical Journal
Background: If the cervix begins to dilate and efface before the 37th week of gestation, it is considered preterm labor. This condition is characterized by strong, frequent uterine contractions.
Ahmed Khalil, Abdelmoneim Zakaria, Yasser Diab   +2 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Analysis of fall-related adverse events among older adults using the Japanese Adverse Drug Event Report (JADER) database

Journal of Pharmaceutical Health Care and Sciences, 2018
Background Falls are a common but serious problem in older adults, and may lead to fractures and bleeding. As many factors, such as medication, aging, and comorbid diseases may simultaneously affect fall-related adverse events (AEs) in older adults, we ...
Haruna Hatahira, Shiori Hasegawa, Sayaka Sasaoka, Yamato Kato, Junko Abe, Yumi Motooka, Akiho Fukuda, Misa Naganuma, Satoshi Nakao, Ririka Mukai, Kazuyo Shimada, Kouseki Hirade, Takeshi Kato, Mitsuhiro Nakamura   +13 more
doaj   +1 more source

Managing new-onset atrial fibrillation in critically ill patients: a systematic narrative review

BMJ Open, 2020
Objectives The aim of this review is to summarise the latest evidence on efficacy and safety of treatments for new-onset atrial fibrillation (NOAF) in critical illness.Participants Critically ill adult patients who developed NOAF during admission.Primary
Oliver C Redfern, J Duncan Young, Tatjana Petrinic, Peter J Watkinson, Liam Joseph O'Bryan, Jonathan Bedford   +5 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Long-term effects of antihypertensive medications on bone mineral density in men older than 55 years

Clinical Interventions in Aging, 2014
Kamil Serkan Ağaçayak,1 Sedat Güven,2 Mahmut Koparal,1 Nedim Güneş,1 Yusuf Atalay,3 Serhat Atilgan11Department of Oral and Maxillofacial Surgery, 2Department of Prosthodontics, School of Dentistry, University of Dicle, Diyarbakir, Turkey;
Ağaçayak KS, Güven S, Koparal M, Güneş N, Atalay Y, Atilgan S   +5 more
doaj  

A Rare Case Report of Amlodipine-Induced Gingival Enlargement and Review of Its Pathogenesis

Case Reports in Dentistry, 2013
Gingival enlargement is a common clinical feature of gingival and periodontal diseases. It is an unwanted side effect of certain systemic drugs given for nondental treatment.
Sanjeev Joshi, Sucheta Bansal
doaj   +1 more source

Pre-injury beta blocker use does not affect the hyperdynamic response in older trauma patients

Journal of Emergencies, Trauma and Shock, 2014
Purpose: Trauma dogma dictates that the physiologic response to injury is blunted by beta-blockers and other cardiac medications. We sought to determine how the pre-injury cardiac medication profile influences admission physiology and post-injury ...
David C Evans, Kendrick M Khoo, Andrei Radulescu, Charles H Cook, Anthony T Gerlach, Thomas J Papadimos, Steven M Steinberg, Stanislaw PA Stawicki, Daniel S Eiferman   +8 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source