Results 61 to 70 of about 449,480 (336)

Analysis of fall-related adverse events among older adults using the Japanese Adverse Drug Event Report (JADER) database

Journal of Pharmaceutical Health Care and Sciences, 2018
Background Falls are a common but serious problem in older adults, and may lead to fractures and bleeding. As many factors, such as medication, aging, and comorbid diseases may simultaneously affect fall-related adverse events (AEs) in older adults, we ...
Haruna Hatahira, Shiori Hasegawa, Sayaka Sasaoka, Yamato Kato, Junko Abe, Yumi Motooka, Akiho Fukuda, Misa Naganuma, Satoshi Nakao, Ririka Mukai, Kazuyo Shimada, Kouseki Hirade, Takeshi Kato, Mitsuhiro Nakamura   +13 more
doaj   +1 more source

Preventing β-Cell Loss and Diabetes With Calcium Channel Blockers

Diabetes, 2012
Although loss of functional β-cell mass is a hallmark of diabetes, no treatment approaches that halt this process are currently available. We recently identified thioredoxin-interacting protein (TXNIP) as an attractive target in this regard.
Guanlan Xu, Junqin Chen, Gu Jing, A. Shalev   +3 more
semanticscholar   +1 more source

Guidelines for pre-operative cardiac risk assessment and perioperative cardiac management in non-cardiac surgery : the Task Force for Preoperative Cardiac Risk Assessment and Perioperative Cardiac Management in Non-cardiac Surgery of the European Society of Cardiology (ESC) and endorsed by the European Society of Anaesthesiology (ESA) [PDF]

, 2009
Non-cardiac surgery; Pre-operative cardiac risk assessment; Pre-operative cardiac testing; Pre-operative coronary artery revascularization; Perioperative cardiac management; Renal disease; Pulmonary disease; Neurological disease; Anaesthesiology; Post ...
Don Poldermans, Jeroen J. Bax, Eric Boersma, Stefan De Hert, Erik Eeckhout, Gerry Fowkes, Bulent Gorenek, Michael G. Hennerici, Bernard Iung, Malte Kelm, Keld Per Kjeldsen, Steen Dalby Kristensen, Jose Lopez-Sendon, Paolo Pelosi, François Philippe, Luc Pierard, Piotr Ponikowski, Jean-Paul Schmid, Olav F.M. Sellevold, Rosa Sicari, Greet Van den Berghe, Frank Vermassen, Sanne E. Hoeks, Ilse Vanhorebeek, Alec Vahanian, Angelo Auricchio, Jeroen J. Bax, Claudio Ceconi, Veronica Dean, Gerasimos Filippatos, Christian Funck-Brentano, Richard Hobbs, Peter Kearney, Theresa McDonagh, Keith McGregor, Bogdan A. Popescu, Zeljko Reiner, Udo Sechtem, Per Anton Sirnes, Michal Tendera, Panos Vardas, Petr Widimsky, Raffaele De Caterina, Stefan Agewall, Nawwar Al Attar, Felicita Andreotti, Stefan D. Anker, Gonzalo Baron-Esquivias, Guy Berkenboom, Laurent Chapoutot, Renata Cifkova, Pompilio Faggiano, Simon Gibbs, Henrik Steen Hansen, Laurence Iserin, Carsten W. Israel, Ran Kornowski, Nekane Murga Eizagaechevarria, Mauro Pepi, Massimo Piepoli, Hans Joachim Priebe, Martin Scherer, Janina Stepinska, David Taggart, Marco Tubaro, Schwartz, Almanaseer, Poldermans, Lee, Boersma, Poldermans, Poldermans, Poldermans, Devereaux, Naughton, Mangano, Ferguson, Carroll, National Center for Health Statistics, Hoeks, Hoeks, Hoeks, Wirthlin, Fleisher, Schouten, Blankensteijn, Holte, Nguyen, Gurusamy, Hlatky, Fletcher, Biccard, Wiklund, Morris, Detsky, Goldman, Maisel, Thygesen, Sabatine, Cannon, Priebe, Tsimikas, Wang, Omland, Bibbins-Domingo, Feringa, Dernellis, Rodseth, Cuthbertson, Cuthbertson, Fox, Jeger, Noordzij, Klocke, Kertai, Etchells, Shaw, Elhendy, Sicari, Das, Nandalur, Rerkpattanapipat, Danias, Hamon, Gerber, Pouleur, Boersma, Reilly, Brunelli, Older, Piepoli, Bassand, Silber, Van de Werf, Cruickshank, Raby, Brady, Juul, Mangano, Yang, Zaugg, Auerbach, McGory, Schouten, Stevens, Bangalore, Devereaux, Wiesbauer, Beattie, Lindenauer, Dunkelgrun, Hoeks, Shammash, Dickstein, Paravastu, van Gestel, Feringa, Boersma, Graham, Rosenson, Hindler, Williams, Durazzo, Schouten, Schouten, Schouten, Coriat, Dodds, Sun, Oosterga, Filion, Wijeysundera, Kertai, Shchukin Iu, Oliver, Wallace, Wijeysundera, Vitez, Macdonald, Shah, Domanski, Lindblad, Robless, Burger, Biondi-Zoccai, Douketis, Vahanian, De Caterina, Pengo, Poldermans, Eagle, Huber, Kaluza, Howard-Alpe, Nuttall, Rabbitts, Douketis, McFalls, Poldermans, Serruys, Kazmers, Hammill, Bhatia, Karagiannis, Feringa, Mancia, Weksler, Iung, Kertai, Vahanian, Habib, Wilson, Forrest, Forrest, Katz, Bertrand, Zipes, Amar, Cox, O'Kelly, Polanczyk, Amar, Atlee, Fuster, Maisel, Balser, Balser, Bayliff, Jakobsen, Mahla, Vardas, Eagle, Gregoratos, Erdman, Potyk, Simon, Shapiro, Madigan, Pinski, Cockcroft, Kertai, Welten, Kheterpal, McCullough, Merten, Maioli, Salem, Murkin, Newman, Selim, Armstrong, Sin, Ramakrishna, Welten, van Gestel, Galiè, Biagini, Leung, Leung, Kaplan, London, Landesberg, Kertai, Landesberg, Martinez, Drew, Landesberg, Fleisher, Mangano, Mangano, London, Eisenberg, Practice guidelines for perioperative transesophageal echocardiography, Polanczyk, Sandham, Feringa, Noordzij, Umpierrez, Vanhorebeek, van den Berghe, Van den Berghe, Gandhi, Ammori, Ellger, Finfer, De Hert, Slogoff, Rodgers, Wu, Bode, Mauermann, Rigg, Birkmeyer, Liu, White, Polomano, Dolin, Jorgensen, Block, Schug   +299 more
core   +3 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Pre-injury beta blocker use does not affect the hyperdynamic response in older trauma patients

Journal of Emergencies, Trauma and Shock, 2014
Purpose: Trauma dogma dictates that the physiologic response to injury is blunted by beta-blockers and other cardiac medications. We sought to determine how the pre-injury cardiac medication profile influences admission physiology and post-injury ...
David C Evans, Kendrick M Khoo, Andrei Radulescu, Charles H Cook, Anthony T Gerlach, Thomas J Papadimos, Steven M Steinberg, Stanislaw PA Stawicki, Daniel S Eiferman   +8 more
doaj   +1 more source

Lack of direct evidence for a functional role of voltage-operated calcium channels in juxtaglomerular cells [PDF]

, 1990
In this study we have examined the role of voltage-gated calcium channels in the regulation of calcium in juxtaglomerular cells. Using a combination of patch-clamp and single-cell calcium measurement we obtained evidence neither for voltage-operated ...
Chegini, S., Kurtz, Armin, Penner, R., Skott, O.   +3 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Long-term effects of antihypertensive medications on bone mineral density in men older than 55 years

Clinical Interventions in Aging, 2014
Kamil Serkan Ağaçayak,1 Sedat Güven,2 Mahmut Koparal,1 Nedim Güneş,1 Yusuf Atalay,3 Serhat Atilgan11Department of Oral and Maxillofacial Surgery, 2Department of Prosthodontics, School of Dentistry, University of Dicle, Diyarbakir, Turkey;
Ağaçayak KS, Güven S, Koparal M, Güneş N, Atalay Y, Atilgan S   +5 more
doaj  

Blockade of current through single calcium channels by trivalent lanthanide cations. Effect of ionic radius on the rates of ion entry and exit. [PDF]

, 1990
Currents flowing through single dihydropyridine-sensitive Ca2+ channels were recorded from cell-attached patches on C2 myotubes. In the presence of dihydropyridine agonist to prolong the duration of single-channel openings, adding micromolar ...
Lansman, JB
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source