Results 61 to 70 of about 149,426 (354)

The fourth-generation Calcium channel blocker: Cilnidipine

Indian Heart Journal, 2013
Several classes of antihypertensive agents have been in clinical use, including diuretics, α-blockers, β-blockers, angiotensin converting enzyme (ACE) inhibitors, angiotensin II type 1 receptor blockers (ARB), and organic calcium channel blockers (CCBs).
K. Sarat Chandra, G. Ramesh
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Long-term effects of antihypertensive medications on bone mineral density in men older than 55 years

Clinical Interventions in Aging, 2014
Kamil Serkan Ağaçayak,1 Sedat Güven,2 Mahmut Koparal,1 Nedim Güneş,1 Yusuf Atalay,3 Serhat Atilgan11Department of Oral and Maxillofacial Surgery, 2Department of Prosthodontics, School of Dentistry, University of Dicle, Diyarbakir, Turkey;
Ağaçayak KS, Güven S, Koparal M, Güneş N, Atalay Y, Atilgan S   +5 more
doaj  

Angiotensin II blockade and aortic-root dilation in Marfan's syndrome [PDF]

, 2008
Background: Progressive enlargement of the aortic root, leading to dissection, is the main cause of premature death in patients with Marfan's syndrome. Recent data from mouse models of Marfan's syndrome suggest that aortic-root enlargement is caused by ...
Brooke, Benjamin S., Dietz, Harry C., Habashi, Jennifer P., Judge, Daniel P., Loeys, Bart, Patel, Nishant   +5 more
core   +2 more sources

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Delayed allergic reaction to amlodipine with a positive lymphocyte transformation test

Revista Alergia México, 2017
Background: Amlodipine is one of the third generation dihydropyridine calcium channel blockers used for hypertension. Mild, moderate and severe reactions have been reported with calcium channel blockers.
Olga Patricia Monge-Ortega, Javier Domínguez-Ortega, Miguel González-Muñoz, Rosario Cabañas, Magdalena Lluch-Bernal, Ana Fiandor, Luz Yadira Bravo-Gallego, Santiago Quirce   +7 more
doaj   +1 more source

Calcium channel blockers and headache [PDF]

British Journal of Clinical Pharmacology, 2006
We recently reported a meta-analysis of 94 randomized placebo-controlled trials of blood pressure-lowering drugs in which the prevalence of headache was reported [1]. On average, one-third fewer people reported headache in the treated groups than in the placebo groups [odds ratio (OR) 0.67; 95% confidence interval (CI) 0.61, 0.74; P < 0.001]. There was
Joan K. Morris, Malcolm Law, Nicholas J. Wald   +2 more
openaire   +3 more sources

Drug-gene interactions of antihypertensive medications and risk of incident cardiovascular disease: a pharmacogenomics study from the CHARGE consortium [PDF]

, 2015
Background Hypertension is a major risk factor for a spectrum of cardiovascular diseases (CVD), including myocardial infarction, sudden death, and stroke.
Arnett, Donna, Avery, Christy L., Bis, Joshua C., Boerwinkle, Eric, Brody, Jennifer A., Buckley, Brendan M., Chen, Yii-Der Ida, Cummings, Steven R., Cupples, L. Adrienne, Davis, Barry R., de Craen, Anton J. M., Demissie, Serkalem, Eckfeldt, John H., Evans, Daniel S., Ford, Ian, Franco, Oscar H., Gudnason, Vilmundur, Harris, Tamara B., Heckbert, Susan R., Hofman, Albert, Ikram, M. Arfan, Irvin, Ryan, Jukema, J. Wouter, Krijthe, Bouwe P., Lange, Leslie A., Launer, Lenore J., Li, Xiaohui, Liu, Yongmei, Lumley, Thomas, Musani, Solomon K., Post, Wendy, Psaty, Bruce M., Quibrera, P. Miguel, Rotter, Jerome I., Sattar, Naveed, Sitlani, Colleen, Slagboom, P. Eline, Smith, Albert Vernon, Smith, Nicholas L., Sotoodehnia, Nona, Stott, David J., Stricker, Bruno H., Stürmer, Til, Sun, Fangui, Taylor, Herman A., Taylor, Kent D., Tranah, Gregory J., Trompet, Stella, Uitterlinden, Andre G., Vasan, Ramachandran S., Westendorp, Rudi, Whitsel, Eric A., Wiggins, Kerri L., Wilson, James G.   +53 more
core   +4 more sources

Downregulation of sST2, a decoy receptor for interleukin‐33, enhances subcutaneous tumor growth in murine pancreatic cancer cells

FEBS Open Bio, EarlyView.
Subcutaneous implantation of murine Panc02 pancreatic cancer cells depleted of sST2, a soluble decoy receptor for the proinflammatory interleukin‐33 (IL‐33), leads to a decreased number of GLUT4‐positive cancer‐associated adipocytes, reduced levels of the anti‐inflammatory molecule adiponectin, increased phosphorylation of IκBα, elevated Cxcl3 ...
Miho Akimoto, Nobuko Koshikawa, Takao Morinaga, Mimi Tamamori‐Adachi, Atsushi Takatori, Keizo Takenaga   +5 more
wiley   +1 more source