Results 81 to 90 of about 98,250 (221)

THE EFFECTIVENESS OF LERCANIDIPINE IN REDUCING THE RISK OF ARTERIAL HYPERTENSION COMPLICATIONS

Рациональная фармакотерапия в кардиологии, 2015
Despite progress in reducing the risk of hypertension (HT) complications, control of blood pressure (BP) levels remains inadequate. Dihydropyridine calcium channel blockers show antihypertensive effect due to significant vasoselective action with a ...
E. EL. Trisvetova
doaj   +3 more sources

Positive feedback loop between MAPK and aquaporin 7 regulates autophagy and apoptosis induced by palmitate in RIN‐m5f cells

FEBS Open Bio, EarlyView.
T2DM is characterized by peripheral blood insulin resistance and progressive pancreatic β‐cell dysfunction. Here, we showed that AQP7, the only aquaglyceroporin protein, regulates autophagy and apoptosis in pancreatic β‐cells. We propose the existence of a positive feedback loop between MAPK signaling and AQP7 that regulates autophagy and apoptosis in ...
Maoqi Wang, Jiang Tan, Xueting He, Yuqin Chen, Guoping Qiu, Mei Yang   +5 more
wiley   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

FEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
wiley   +1 more source

Role of calcium in morphine dependence and naloxone-precipitated withdrawal in mice

Journal of Experimental Pharmacology, 2011
Vikas Seth, Prerna Upadhyaya, Vijay Moghe, Mushtaq AhmadDepartment of Pharmacology, Mahatma Gandhi Medical College, Jaipur, Rajasthan, IndiaPurpose: To explore the role of calcium in morphine withdrawal syndrome using various agents affecting calcium ...
Vikas Seth, Prerna Upadhyaya, Vijay Moghe, et al   +3 more
doaj  

A Modern View on the Treatment for Acute Calcium Channel Blocker Poisoning

Неотложная медицинская помощь
BACKGROUND. At the beginning of the 21st century, the structure of acute exotoxicoses changed, in particular, an increase in poisoning by drugs that mainly affect the cardiovascular system, including calcium channel blockers, was noted.
A. Yu. Simonova, K. K. Ilyashenko, M. M. Potskhveriya, M. V. Belova, L. R. Asanova   +4 more
doaj   +1 more source

Study of Effect of Amlodipine on Blood Sugar Level

Asian Journal of Medical Sciences, 2010
Objective: To study the effect of AMLODIPINE on blood sugar levels in hypertensive patients. Method: It is a prospective study in which patients were selected from Princess Esra hospital, Hyderabad.
Tasneem Sandozi
doaj   +1 more source

Prevalence of gingival overgrowth induced by antihypertensive drugs: A hospital-based study

Journal of Indian Society of Periodontology, 2015
Background: Gingival overgrowth (GO) is a known side-effect of calcium channel blockers. Although there have been several case reports, few studies have examined the prevalence of nifedipine, diltiazem, and amlodipine.
Saumiya Gopal, Rosamma Joseph, Vediyera Chandroth Santhosh, Vadakkedath Venugopal Harish Kumar, Shiny Joseph, Abhijeet Rajendra Shete   +5 more
doaj   +1 more source

Improving VMAT dose calculation accuracy and planning quality via a GPU‐accelerated Fourier transform dose calculation algorithm

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Background Inverse planning typically utilizes fast, less accurate dose calculation algorithms during the iterative optimization process, thus leading to dose calculation errors (DCEs) and suboptimal plans that often require dose normalization and/or plan re‐optimization.
Kenny Guida, Chaoqiong Ma, Joy Patel, Krishna Reddy, H. Harold Li   +4 more
wiley   +1 more source

Design and synthesis of novel 4-substituted 1,4-dihydropyridine derivatives as hypotensive agents

Journal of Saudi Chemical Society, 2016
Calcium-channel blockers have an important role in the treatment of several cardiovascular disorders. Derivatives of 1,4-dihydropyridines are one of the most potent calcium antagonists.
Prasanna A. Datar, Pratibha B. Auti
doaj   +1 more source