Results 1 to 10 of about 20,375,767 (303)

Postnatal refinement of CaV channel isoform composition, electrical activity, and insulin release in mouse pancreatic β-cells [PDF]

Channels
Pancreatic β-cell mass and glucose-stimulated insulin secretion strongly increase during postnatal development. Voltage-gated calcium channels (CaV) are the key determinants of pancreatic β-cell electrical activity, insulin granule exocytosis, β-cell ...
Tamara Theiner, Noelia Jacobo-Piqueras, Dorina Tota, Petronel Tuluc   +3 more
doaj   +2 more sources

Pathophysiology of Cav1.3 L-type calcium channels in the heart

Frontiers in Physiology, 2023
Ca2+ plays a crucial role in excitation-contraction coupling in cardiac myocytes. Dysfunctional Ca2+ regulation alters the force of contraction and causes cardiac arrhythmias. Ca2+ entry into cardiomyocytes is mediated mainly through L-type Ca2+ channels,
Sahil Zaveri, Sahil Zaveri, Ujala Srivastava, Yongxia Sarah Qu, Yongxia Sarah Qu, Yongxia Sarah Qu, Mohamed Chahine, Mohamed Chahine, Mohamed Boutjdir, Mohamed Boutjdir, Mohamed Boutjdir   +10 more
doaj   +3 more sources

Aging Alters the Formation and Functionality of Signaling Microdomains Between L-type Calcium Channels and β2-Adrenergic Receptors in Cardiac Pacemaker Cells

Frontiers in Physiology, 2022
Heart rate is accelerated to match physiological demands through the action of noradrenaline on the cardiac pacemaker. Noradrenaline is released from sympathetic terminals and activates β1-and β2-adrenergic receptors (ΑRs) located at the plasma membrane ...
Sabrina Choi, Oscar Vivas, Matthias Baudot, Claudia M. Moreno   +3 more
doaj   +1 more source

The calmodulin-binding, short linear motif, NSCaTE is conserved in L-type channel ancestors of vertebrate Cav1.2 and Cav1.3 channels. [PDF]

PLoS ONE, 2013
NSCaTE is a short linear motif of (xWxxx(I or L)xxxx), composed of residues with a high helix-forming propensity within a mostly disordered N-terminus that is conserved in L-type calcium channels from protostome invertebrates to humans.
Valentina Taiakina, Adrienne N Boone, Julia Fux, Adriano Senatore, Danielle Weber-Adrian, J Guy Guillemette, J David Spafford   +6 more
doaj   +1 more source

Calcium Channels in the Heart: Disease States and Drugs

Cells, 2022
Calcium ions are the major signaling ions in the cells. They regulate muscle contraction, neurotransmitter secretion, cell growth and migration, and the activity of several proteins including enzymes and ion channels and transporters. They participate in
Kajol Shah, Sarah Seeley, Castin Schulz, Jacqueline Fisher, Shubha Gururaja Rao   +4 more
doaj   +1 more source

Denitration of L‐type calcium channel [PDF]

FEBS Letters, 2008
Tyrosine nitration results in altered function of selective proteins, including human smooth muscle L‐type calcium channel, hCav1.2b. We report here that Cav1.2 is also subject to “denitration”. Cell lysates from activated macrophage‐like cell line, RAW264.7 cells, reversed peroxynitrite‐induced nitration of the carboxy terminus of Cav1.2 in a 1D gel ...
Kang, Minho, Akbarali, Hamid I.
openaire   +2 more sources

Intercommunication between Voltage-Gated Calcium Channels and Estrogen Receptor/Estrogen Signaling: Insights into Physiological and Pathological Conditions

Cells, 2022
Voltage-gated calcium channels (VGCCs) and estrogen receptors are important cellular proteins that have been shown to interact with each other across varied cells and tissues.
Yashashwini Dinesh Subbamanda, Anamika Bhargava   +1 more
doaj   +1 more source

Forskolin Regulates L-Type Calcium Channel through Interaction between Actinin 4 and β3 Subunit in Osteoblasts. [PDF]

PLoS ONE, 2015
Voltage-dependent L-type calcium channels that permit cellular calcium influx are essential in calcium-mediated modulation of cellular signaling. Although the regulation of voltage-dependent L-type calcium channels is linked to many factors including ...
Xuemei Zhang, Fangping Li, Lin Guo, Hongya Hei, Lulu Tian, Wen Peng, Hui Cai   +6 more
doaj   +1 more source

Potential binding modes of the gut bacterial metabolite, 5-hydroxyindole, to the intestinal L-type calcium channels and its impact on the microbiota in rats

Gut Microbes, 2023
Intestinal microbiota and microbiota-derived metabolites play a key role in regulating the host physiology. Recently, we have identified a gut-bacterial metabolite, namely 5-hydroxyindole, as a potent stimulant of intestinal motility via its modulation ...
Barbora Waclawiková, Paulo Cesar Telles de Souza, Markus Schwalbe, Constantinos G. Neochoritis, Warner Hoornenborg, Sieger A. Nelemans, Siewert J. Marrink, Sahar El Aidy   +7 more
doaj   +1 more source

Antihypertensive Effect of a Novel Angiotensin II Receptor Blocker Fluorophenyl Benzimidazole: Contribution of cGMP, Voltage-dependent Calcium Channels, and BKCa Channels to Vasorelaxant Mechanisms

Frontiers in Pharmacology, 2021
Background: The current study presents the novel angiotensin II receptor blocker fluorophenyl benzimidazole (FPD) as an antihypertensive agent in the SHR model of hypertension.
Hina Iqbal, Amit Kumar Verma, Pankaj Yadav, Sarfaraz Alam, Mohammad Shafiq, Divya Mishra, Feroz Khan, Kashif Hanif, Arvind Singh Negi, Debabrata Chanda   +9 more
doaj   +1 more source