L-type calcium channel modulation reveals the relationship between neuronal synchrony and hyperactivity in the inferior colliculus following noise-induced hearing loss. [PDF]
Sci RepYalcinoglu S +5 more
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Progress in the study of ion channel function, mechanisms, and mathematical modeling in Parkinson's disease. [PDF]
iScienceWang R, Zeng X, Zhang Z, Ma D.
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Differential Sensitivity of TRPC- and ORAI-Mediated Calcium Entries to 1‑[2-(4-Methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]imidazole Chloride (SKF-96365). [PDF]
ACS Pharmacol Transl SciSusperreguy S +4 more
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Dental drugs with proarrhythmic risk in patients with Brugada syndrome: precaution instructions for practices in the field of orofacial pain. [PDF]
Front Cardiovasc MedHan D, Cho NY, Cho ES, Roh SY.
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The Synaptic and Intrinsic Cellular Mechanisms of Persistent Firing in Neurogliaform Cells. [PDF]
BiomoleculesChen S +7 more
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Hypomagnesemia: A Clinical and Nutritional Update. [PDF]
Curr Nutr RepPapagiannidou A +6 more
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Assays for L-type voltage gated calcium channels
Analytical Biochemistry, 2022Voltage gated calcium channels (VGCCs) are pursued as drug targets for neurodegenerative and cardiovascular diseases. High throughput drug screening targeting VGCCs depends on patch-clamp electrophysiology or fluorophore-based calcium imaging that requires powerful equipment and specialized expertise thus leading to cost escalation.
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L-Type Calcium Channel Disease
2008In recent years, the progress of molecular genetics of inherited arrhythmogenic diseases portrays an unexpected complexity of clinical phenotypes associated with mutations in several genes that control cardiac excitability. Among the most recent findings, the voltage-gated L-type cardiac calcium channel (Cav1.2) has been involved in the pathogenesis of
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