Results 41 to 50 of about 238,547 (309)
Tweeters and Woofers: The Complex Orchestra of Calcium Currents in T Lymphocytes
Frontiers in Immunology, 2015 Elevation of intracellular calcium ion (Ca2+) levels is a vital event that regulates T lymphocyte homeostasis, activation, proliferation, differentiation, and apoptosis.
Lilian L Nohara +12 more
doaj +1 more source
Unveiling (−)‐Englerin A as a Modulator of L‐Type Calcium Channels
Angewandte Chemie, 2016 The voltage‐dependent L‐type Ca2+channel was identified as a macromolecular target for (−)‐englerin A. This finding was reached by using an unprecedented ligand‐based prediction platform and the natural product piperlongumine as a pharmacophore probe. (−)
T. Rodrigues +6 more
semanticscholar +1 more source
L-type calcium channel auto-regulation of transcription [PDF]
Cell Calcium, 2011 L-type calcium channels (LTCC) impact the function of nearly all excitable cells. The classical LTCC function is to mediate trans-sarcolemmal Ca(2+) flux. This review focuses on the contribution of a mobile segment of the LTCC that regulates ion channel function, and also serves as a regulator of transcription in the nucleus.
Jonathan, Satin +2 more
openaire +2 more sources
Neuroprotective effects of blockers for T-type calcium channels
Molecular Neurodegeneration, 2009 Cognitive and functional decline with age is correlated with deregulation of intracellular calcium, which can lead to neuronal death in the brain.
Lei Debin +4 more
doaj +1 more source
Pathophysiology of Cav1.3 L-type calcium channels in the heart
Frontiers in Physiology, 2023 Ca2+ plays a crucial role in excitation-contraction coupling in cardiac myocytes. Dysfunctional Ca2+ regulation alters the force of contraction and causes cardiac arrhythmias. Ca2+ entry into cardiomyocytes is mediated mainly through L-type Ca2+ channels,
Sahil Zaveri +10 more
doaj +1 more source
Current Therapeutic Research, 2023 : Background: Cilnidipine is a fourth-generation calcium channel blocker that is clinically used to treat hypertension. It is a dihydropyridine that blocks L- and N-type calcium channels.
Steffi A. Maria, MD +4 more
doaj +1 more source
Psychostimulants, L-type Calcium Channels, Kinases, and Phosphatases [PDF]
The Neuroscientist, 2005 There is growing evidence for the role of voltage-gated L-type Ca2+ channels in mediating aspects of the addictive properties of psychostimulants. L-type Ca2+ channels activate Ca2+ second-messenger pathways that regulate protein phosphorylation and thereby activation of target gene expression.
Anjali M, Rajadhyaksha +1 more
openaire +2 more sources
Differential calcium signaling mediated by voltage-gated calcium channels in rat retinal ganglion cells and their unmyelinated axons. [PDF]
PLoS ONE, 2014 Aberrant calcium regulation has been implicated as a causative factor in the degeneration of retinal ganglion cells (RGCs) in numerous injury models of optic neuropathy.
Allison Sargoy +3 more
doaj +1 more source
The Voltage-Gated Calcium Channel EGL-19 Acts on Glia to Drive Olfactory Adaptation
Frontiers in Molecular Neuroscience, 2022 Calcium channelopathies have been strongly linked to cardiovascular, muscular, neurological and psychiatric disorders. The voltage-gated calcium channels (VGCC) are vital transducers of membrane potential changes to facilitate the dynamics of calcium ...
Du Chen +17 more
doaj +1 more source
Journal of Physiology, 2015 The voltage‐gated Ca2+ channels (VGCCs) that catalyse striatal dopamine transmission are critical to dopamine function and might prime subpopulations of neurons for parkinsonian degeneration.
Katherine R. Brimblecombe +3 more
semanticscholar +1 more source