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T-Type Calcium Channels: A Mixed Blessing
International Journal of Molecular Sciences, 2022 The role of T-type calcium channels is well established in excitable cells, where they preside over action potential generation, automaticity, and firing. They also contribute to intracellular calcium signaling, cell cycle progression, and cell fate; and,
Dario Melgari +5 more
semanticscholar +3 more sources
Molecular Brain, 2021 T-type calcium channels are known molecular targets of certain phytocannabinoids and endocannabinoids. Here we explored the modulation of Cav3.2 T-type calcium channels by terpenes derived from cannabis plants.
Vinicius M. Gadotti +2 more
doaj +2 more sources
T-type Calcium Channels in Cancer [PDF]
Cancers, 2019 Although voltage-activated Ca2+ channels are a common feature in excitable cells, their expression in cancer tissue is less understood. T-type Ca2+ channels are particularly overexpressed in various cancers.
Lauren Antal, Miguel Martin-Caraballo
semanticscholar +3 more sources
Emerging roles of L-type voltage gated and other calcium channels in T lymphocytes. [PDF]
Frontiers in Immunology, 2013 In T lymphocytes, calcium ion controls a variety of biological processes including development, survival, proliferation, and effector functions. These distinct and specific roles are regulated by different calcium signals, which are generated by various ...
Abdallah eBadou +4 more
doaj +3 more sources
Central and peripheral contributions of T-type calcium channels in pain
Molecular Brain, 2022 Chronic pain is a severely debilitating condition that reflects a long-term sensitization of signal transduction in the afferent pain pathway. Among the key players in this pathway are T-type calcium channels, in particular the Cav3.2 isoform. Because of
Erika K. Harding, Gerald W. Zamponi
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Targetable T-type Calcium Channels Drive Glioblastoma. [PDF]
Cancer Research, 2017 Abstract Glioblastoma (GBM) stem-like cells (GSC) promote tumor initiation, progression, and therapeutic resistance. Here, we show how GSCs can be targeted by the FDA-approved drug mibefradil, which inhibits the T-type calcium channel Cav3.2.
Ying Zhang +16 more
semanticscholar +3 more sources
Scientific Reports, 2021 Homeostatic plasticity stabilizes neuronal networks by adjusting the responsiveness of neurons according to their global activity and the intensity of the synaptic inputs.
Anikó Rátkai +5 more
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T-type calcium channels in synaptic plasticity [PDF]
Channels, 2017 The role of T-type calcium currents is rarely considered in the extensive literature covering the mechanisms of long-term synaptic plasticity. This situation reflects the lack of suitable T-type channel antagonists that till recently has hampered ...
N. Leresche, R. Lambert
semanticscholar +4 more sources
Intrinsic calcium resonance and its modulation: insights from computational modeling [PDF]
Frontiers in Computational NeuroscienceHippocampal neurons generate membrane potential resonance due to specific voltage-gated ion channels, known as resonating conductances, which play crucial physiological roles.
Rahul Kumar Rathour, Hanoch Kaphzan
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T-type calcium channels in neuropathic pain [PDF]
Pain, 2016 Pain is a quite frequent complaint accompanying numerous pathologies. Among these pathological cases, numerous neuropathies are retrieved with identified etiologies (chemotherapies, diabetes, surgeries…) and also more diffuse syndromes such as fibromyalgia. More broadly, pain is one of the first consequences of most inherited diseases.
E. Bourinet +2 more
semanticscholar +4 more sources