Results 11 to 20 of about 411,380 (346)
Frontiers in Molecular Neuroscience, 2018 Injuries to peripheral nerve fibers induce neuropathic pain. But the involvement of adjacent uninjured fibers to pain is not fully understood. The present study aims to investigate the possible contribution of Cav3.2 T-type calcium channels in uninjured ...
Wen Chen +20 more
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The role of T-type calcium channel genes in absence seizures [PDF]
Frontiers in Neurology, 2014 The thalamic relay neurons, reticular thalamic nucleus, and neocortical pyramidal cells form a circuit that sustains oscillatory burst firing, and is regarded as the underlying mechanism of absence seizures.
Yucai eChen +3 more
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Activity-dependent regulation of T-type calcium channels by submembrane calcium ions
eLife, 2017 Voltage-gated Ca2+ channels are involved in numerous physiological functions and various mechanisms finely tune their activity, including the Ca2+ ion itself.
Magali Cazade +3 more
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Noradrenaline upregulates T‐type calcium channels in rat pinealocytes [PDF]
The Journal of Physiology, 2015 Key pointsThe mammalian pineal gland is a neuroendocrine organ that responds to circadian and seasonal rhythms. Its major function is to secrete melatonin as a hormonal night signal in response to nocturnal delivery of noradrenaline from sympathetic neurons.Culturing rat pinealocytes in noradrenaline for 24 h induced a low‐voltage activated transient ...
Haijie Yu +4 more
semanticscholar +3 more sources
T‐type calcium channels as therapeutic targets in essential tremor and Parkinson's disease
Annals of Clinical and Translational Neurology, 2023 Neuronal action potential firing patterns are key components of healthy brain function. Importantly, restoring dysregulated neuronal firing patterns has the potential to be a promising strategy in the development of novel therapeutics for disorders of ...
Lillian G. Matthews +6 more
semanticscholar +1 more source
Calcium Channels in the Heart: Disease States and Drugs
Cells, 2022 Calcium ions are the major signaling ions in the cells. They regulate muscle contraction, neurotransmitter secretion, cell growth and migration, and the activity of several proteins including enzymes and ion channels and transporters. They participate in
Kajol Shah +4 more
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Inhibition of human recombinant T‐type calcium channels by phytocannabinoids in vitro
British Journal of Pharmacology, 2022 T‐type Ca channels (ICa) regulate neuronal excitability and contribute to neurotransmitter release. The phytocannabinoids Δ9‐tetrahydrocannabinol and cannabidiol effectively modulate T‐type ICa, but effects of other biologically active phytocannabinoids ...
Somayeh Mirlohi +5 more
semanticscholar +1 more source
Estradiol enhances T-type calcium channel activation in human myometrium telocytes
The Journal of Reproduction and Development, 2023 Uterine peristalsis is essential for gamete transport and embryo implantation. It shares the characteristics of spontaneity, rhythmicity, and directivity with gastrointestinal peristalsis.
Lin ZHU +6 more
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Cells, 2022 Voltage-gated calcium channels (VGCCs) and estrogen receptors are important cellular proteins that have been shown to interact with each other across varied cells and tissues.
Yashashwini Dinesh Subbamanda +1 more
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Cells, 2023 Calcium (Ca2+) can regulate a wide variety of cellular fates, such as proliferation, apoptosis, and autophagy. More importantly, changes in the intracellular Ca2+ level can modulate signaling pathways that control a broad range of physiological as well ...
Ankush Sharma +3 more
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