Results 291 to 300 of about 411,380 (346)

Aldosterone regulation of T-type calcium channels

The Journal of Steroid Biochemistry and Molecular Biology, 2003
Voltage-operated calcium channels play a crucial role in signal transduction in many excitable and non-excitable cell types. While a rapid modulation of their activity by hormone-activated kinases and/or G proteins has been recognized for a long time, a sustained control of their expression level has been only recently demonstrated.
Michel F, Rossier, Olivier, Lesouhaitier, Emeline, Perrier, Liliane, Bockhorn, Alberto, Chiappe, Nathalie, Lalevée   +5 more
openaire   +2 more sources

A potential role for T-type calcium channels in homocysteinemia-induced peripheral neuropathy.

Pain, 2019
Homocysteinemia is a metabolic condition characterized by abnormally high level of homocysteine in the blood and is considered to be a risk factor for peripheral neuropathy. However, the cellular mechanisms underlying toxic effects of homocysteine on the
Aisylu Gaifullina, J. Lazniewska, E. Gerasimova, Gulshat Burkhanova, Y. Rzhepetskyy, A. Tomin, Paula Rivas-Ramírez, Junting Huang, Leos Cmarko, G. Zamponi, G. Sitdikova, N. Weiss   +11 more
semanticscholar   +1 more source

Modulation of Neuronal T-Type Calcium Channels

CNS & Neurological Disorders - Drug Targets, 2006
As T-type calcium channels open near resting membrane potential and markedly influence neuronal excitability their activity needs to be tightly regulated. Few neuronal T-current regulations have been described so far, but interestingly some of them involve unusual mechanisms like G protein-independent but receptor-coupled modulation, while the use of ...
R C, Lambert, T, Bessaih, N, Leresche
openaire   +2 more sources

Regulation of neuronal T-type calcium channels

Trends in Pharmacological Sciences, 2009
T-type calcium channels are critically important for regulating neuronal excitability, both in the central and peripheral nervous system, and are essential mediators of hormone secretion. Conversely, T-type channel hyperactivity has been linked to neurological disorders such as absence epilepsy and neuropathic pain.
Mircea C, Iftinca, Gerald W, Zamponi
openaire   +2 more sources

Discovery of potent T-type calcium channel blocker

Bioorganic & Medicinal Chemistry Letters, 2007
The intensive SAR study of 3,4-dihydroquinazoline series led to the most potent compound 10 (KYS05090: IC(50)=41+/-1 nM) against T-type calcium channel and its potency is nearly comparable to that of Kurtoxin. As a small organic molecule, this compound showed the highest blocking activity reported to date.
Han Na, Seo, Ja Youn, Choi, Yun Jeong, Choe, Yoonjee, Kim, Hyewhon, Rhim, So Ha, Lee, Jungahn, Kim, Dong Jun, Joo, Jae Yeol, Lee   +8 more
openaire   +2 more sources

Cardiovascular T-type calcium channels

Journal of Hypertension, 1997
CELLULAR CALCIUM REGULATION: A variety of Ca2+ control processes are responsible for Ca2+ homeostasis and signaling. Voltage-gated Ca2+ channels are dominant in the cardiovascular system. VOLTAGE-GATED Ca2+ CHANNELS: There are several distinct subclasses of Ca2+ channels, distinguished by location, biophysical, structural and pharmacological ...
openaire   +2 more sources

T-type Calcium Channels in Health and Disease

Current Medicinal Chemistry, 2020
Low Voltage-Activated (LVA) T-type calcium channels are characterized by transient current and Low Threshold Spikes (LTS) that trigger neuronal firing and oscillatory behavior. Combined with their preferential localization in dendrites and their specific “window current”, T-type calcium channels are considered ...
Dan, Wang, Lotten, Ragnarsson, Richard J, Lewis   +2 more
openaire   +2 more sources

A T-type calcium channel from mouse brain

Pfl�gers Archiv European Journal of Physiology, 1999
A member of the low-voltage-activated calcium channel family was identified in mouse brain by taking advantage of amino acid sequences that have been evolutionary conserved. The identified sequence is similar to that of the recently cloned rat alpha1G T-type calcium channel, but there are differences in two insertions in the intracellular connecting ...
N, Klugbauer, E, Marais, L, Lacinová, F, Hofmann   +3 more
openaire   +2 more sources

T-type calcium channels: The never ending story

Cell Calcium, 2006
T-type, or low-voltage-activated (LVA), tiny and transient Ca2+ currents pare more and more recognised as universal players in a plethora of cell functions and are also more and more connected to several diseases. This short introduction reviews the discovery of T-type Ca2+ channels, describes its basic properties and sketches its cloning and ...
Nilius, Bernd, Talavera, Karel, Verkhratsky, Alexei   +2 more
openaire   +2 more sources

Mibefradil Block of Cloned T-Type Calcium Channels

The Journal of Pharmacology and Experimental Therapeutics, 2000
Mibefradil is a tetralol derivative chemically distinct from other calcium channel antagonists. It is a very effective antihypertensive agent that is thought to achieve its action via a higher affinity block for low-voltage-activated (T) than for high-voltage-activated (L) calcium channels.
R L, Martin, J H, Lee, L L, Cribbs, E, Perez-Reyes, D A, Hanck   +4 more
openaire   +2 more sources