Results 31 to 40 of about 411,380 (346)
Functional Importance of L- and P/Q-Type Voltage-Gated Calcium Channels in Human Renal Vasculature [PDF]
, 2011 Calcium channel blockers are widely used for treatment of hypertension, because they decrease peripheral vascular resistance through inhibition of voltage-gated calcium channels.
Cribbs, Leanne L +6 more
core +1 more source
Scientific Reports, 2020 The spontaneous contractions of collecting lymphatic vessels provide an essential propulsive force to return lymph centrally. These contractions are driven by an intrinsic electrical pacemaker, working through an unknown underlying ionic mechanism that ...
K. H. To +5 more
semanticscholar +1 more source
Neuroprotective effects of blockers for T-type calcium channels
Molecular Neurodegeneration, 2009 Cognitive and functional decline with age is correlated with deregulation of intracellular calcium, which can lead to neuronal death in the brain.
Lei Debin +4 more
doaj +1 more source
T-type calcium channels functionally interact with spectrin (α/β) and ankyrin B
Molecular Brain, 2018 This study describes the functional interaction between the Cav3.1 and Cav3.2 T-type calcium channels and cytoskeletal spectrin (α/β) and ankyrin B proteins.
Agustin Garcia-Caballero +10 more
doaj +1 more source
T Cell Receptor Mediated Calcium Entry Requires Alternatively Spliced Cav1.1 Channels. [PDF]
PLoS ONE, 2016 The process of calcium entry in T cells is a multichannel and multi-step process. We have studied the requirement for L-type calcium channels (Cav1.1) α1S subunits during calcium entry after TCR stimulation. High expression levels of Cav1.1 channels were
Didi Matza +10 more
doaj +1 more source
T-type calcium channel: a privileged gate for calcium entry and control of adrenal steroidogenesis
Frontiers in Endocrinology, 2016 Intracellular calcium plays a crucial role in modulating a variety of functions such as muscle contraction, hormone secretion, gene expression or cell growth. Calcium signaling has been however shown to be more complex than initially thought.
Michel Florian Rossier +1 more
doaj +1 more source
Diindolylmethane Derivatives: New Selective Blockers for T-Type Calcium Channels
Membranes, 2022 The natural product indole-3-carbinol (I3C) and its major digestive product 3,3′-diindolylmethane (DIM) have shown clinical promise in multiple forms of cancer including breast cancer.
Dan Wang +4 more
doaj +1 more source
Role of T-type calcium channels in myogenic tone of skeletal muscle resistance arteries [PDF]
, 2002 T-type calcium channels may be involved in the maintenance of myogenic tone. We tested their role in isolated rat cremaster arterioles obtained after CO2 anesthesia and decapitation.
Andreasen, Ditte +4 more
core +2 more sources
Structure, gating, and pharmacology of human CaV3.3 channel
Nature Communications, 2022 T-type calcium channels are implicated in many diseases. Here, multiple structures of CaV3.3 channel elucidate molecular mechanisms of T-type CaV channels activation at low voltage and interaction with different clinically used channel blockers.
Lingli He +13 more
doaj +1 more source
eLife, 2022 Low voltage-activated calcium currents are mediated by T-type calcium channels CaV3.1, CaV3.2, and CaV3.3, which modulate a variety of physiological processes including sleep, cardiac pace-making, pain, and epilepsy. CaV3 isoforms’ biophysical properties,
Jeffrey R McArthur +4 more
doaj +1 more source