Results 51 to 60 of about 411,380 (346)
T-type calcium channel blockers as neuroprotective agents [PDF]
Pflügers Archiv - European Journal of Physiology, 2014 T-type calcium channels are expressed in many diverse tissues, including neuronal, cardiovascular, and endocrine. T-type calcium channels are known to play roles in the development, maintenance, and repair of these tissues but have also been implicated in disease when not properly regulated. Calcium channel blockers have been developed to treat various
Benjamin J, Kopecky +2 more
openaire +2 more sources
Active dendrites regulate the spatiotemporal spread of signaling microdomains. [PDF]
PLoS Computational Biology, 2018 Microdomains that emerge from spatially constricted spread of biochemical signaling components play a central role in several neuronal computations.
Reshma Basak, Rishikesh Narayanan
doaj +1 more source
Regulation of oxygen sensing by ion channels [PDF]
, 2004 O2 sensing is of critical importance for cell survival and adaptation of living organisms to changing environments or physiological conditions. O2-sensitive ion channels are major effectors of the cellular responses to hypoxia.
Chiara, María D. +4 more
core +1 more source
Journal of Neuroscience, 1999 Low voltage-activated (T-type) calcium currents are observed in many central and peripheral neurons and display distinct physiological and functional properties.
E. Talley +5 more
semanticscholar +1 more source
T-type Ca2+ current activity during oocyte growth and maturation in the ascidian Styela plicata. [PDF]
PLoS ONE, 2013 Voltage-dependent calcium currents play a fundamental role during oocyte maturation, mostly L-type calcium currents, whereas T-type calcium currents are involved in sperm physiology and cell growth.
Alessandra Gallo +2 more
doaj +1 more source
Cav3.2 T-type calcium channels shape electrical firing in mouse Lamina II neurons
Scientific Reports, 2019 The T-type calcium channel, Cav3.2, is necessary for acute pain perception, as well as mechanical and cold allodynia in mice. Being found throughout sensory pathways, from excitatory primary afferent neurons up to pain matrix structures, it is a ...
M. Candelas +17 more
semanticscholar +1 more source
The common features of tetrameric ion channels and the role of electrostatic interactions
Electrochemistry Communications, 2020 The three tetrameric voltage-gated K+, Na+, and Ca2+ ion channels share a high number of common structural features. Moreover, they share a common charge distribution over the corresponding molecular components.
Rolando Guidelli
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The involvement of actin, calcium channels and exocytosis proteins in somato-dendritic oxytocin and vasopressin release [PDF]
, 2012 Hypothalamic magnocellular neurons release vasopressin and oxytocin not only from their axon terminals into the blood, but also from their somata and dendrites into the extracellular space of the brain, and this can be regulated independently ...
Leng, Gareth, Ludwig, Mike, Tobin, Vicky
core +2 more sources
Pain, 2018 The Federal Pain Research Strategy recommended development of nonopioid analgesics as a top priority in its strategic plan to address the significant public health crisis and individual burden of chronic pain faced by >100 million Americans. Motivated by
S. Bellampalli +17 more
semanticscholar +1 more source
Dual role of T-type calcium channels in anxiety-related behavior
Journal of Basic and Clinical Physiology and Pharmacology, 2019 T-type calcium channels are low voltage activated calcium channels that are widely expressed in various brain regions including stress-responsive regions.
Simranjot Kaur +3 more
semanticscholar +1 more source