Results 61 to 70 of about 411,380 (346)

The anticonvulsant phytocannabinoids CBGVA and CBDVA inhibit recombinant T-type channels

Frontiers in Pharmacology, 2022
Introduction: Cannabidiol (CBD) has been clinically approved for intractable epilepsies, offering hope that novel anticonvulsants in the phytocannabinoid class might be developed.
Michael Udoh, Michael Udoh, Michael Udoh, Chris Bladen, Marika Heblinski, Marika Heblinski, Marika Heblinski, Jia Lin Luo, Jia Lin Luo, Jia Lin Luo, Vaishali S. Janve, Vaishali S. Janve, Vaishali S. Janve, Lyndsey L. Anderson, Lyndsey L. Anderson, Lyndsey L. Anderson, Iain S. McGregor, Iain S. McGregor, Iain S. McGregor, Jonathon C. Arnold, Jonathon C. Arnold, Jonathon C. Arnold   +21 more
doaj   +1 more source

Characterization of the molecular and electrophysiological properties of the T-type calcium channel in human myometrium [PDF]

Rises in intracellular calcium are essential for contraction of human myometrial smooth muscle (HMSM) and hence parturition. The T-type calcium channel may play a role in this process.
Anwer, Astle, Challis, Cribbs, Eller, Fry, Garfield, Gomora, Jones, Khan, Khan, Kim, Klockner, Knock, Knock, Lee, Lee, Monteil, Moosmang, Nebe, Ohkubo, Ohkubo, Parkington, Parkington, Perez, Perez-Reyes, Perez-Reyes, Perez-Reyes, Viana, Woodcock, Young, Young, Zamponi   +32 more
core   +2 more sources

Genetics update: monogenetics, polygene disorders and the quest for modifying genes [PDF]

, 2018
The genetic channelopathies are a broad collection of diseases. Many ion channel genes demonstrate wide phenotypic pleiotropy, but nonetheless concerted efforts have been made to characterise genotype-phenotype relationships.
Symonds, Joseph D., Zuberi, Sameer M.
core   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Synthesis and biological evaluation of pyrrolidine-based T-type calcium channel inhibitors for the treatment of neuropathic pain

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
The treatment of neuropathic pain is one of the urgent unmet medical needs and T-type calcium channels are promising therapeutic targets for neuropathic pain.
Hak Kyun Yang, Woo Seung Son, Keon Seung Lim, Gun Hee Kim, Eun Jeong Lim, Changdev G. Gadhe, Jae Yeol Lee, Kyu-Sung Jeong, Sang Min Lim, Ae Nim Pae   +9 more
doaj   +1 more source

Developmental synaptic changes at the transient olivocochlear-inner hair cell synapse [PDF]

, 2019
In the mature mammalian cochlea, inner hair cells (IHCs) are mainly innervated by afferent fibers that convey sound information to the CNS. During postnatal development, however, medial olivocochlear (MOC) efferent fibers transiently innervate the IHCs ...
Elgoyhen, Ana Belen, Katz, Eleonora, Kearney, Graciela Inés, Vattino, Lucas Gabriel, Wedemeyer, Carolina, Zorrilla de San Martín, Javier   +5 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Aldosterone increases T-type calcium channel expression and in vitro beating frequency in neonatal rat cardiomyocytes [PDF]

, 2017
Objective: Although aldosterone has been implicated in the pathogenesis of cardiac hypertrophy and heart failure, its cellular mechanism of action on cardiomyocyte function is not yet completely elucidated.
Barrère-Lemaire, Stéphanie, Bénitah, Jean-Pierre, Lalevé, Nathalie, Nargeot, Joël, Perrier, Emeline, Rebsamen, Michela C., Rossier, Michel F.   +6 more
core  

Vascular smooth muscle contraction in hypertension [PDF]

, 2018
Hypertension is a major risk factor for many common chronic diseases, such as heart failure, myocardial infarction, stroke, vascular dementia and chronic kidney disease.
Alves-Lopes, Rheure, Anagnostopoulou, Aikaterini, Arner, Anders, De Lucca Camargo, Livia, Montezano, Augusto C., Rios, Francisco J., Touyz, Rhian M.   +6 more
core   +1 more source