Results 81 to 90 of about 411,380 (346)
Frontiers in Physiology, 2015 How nature discriminates sodium from calcium ions in eukaryotic channel pores has been difficult to resolve because these are asymmetrical pores, contributed by four different homologous domains.
Robert F. Stephens +4 more
doaj +1 more source
The role of inhibitory G proteins and regulators of G protein signaling in the in vivo control of heart rate and predisposition to cardiac arrhythmias [PDF]
, 2012 Inhibitory heterotrimeric G proteins and the control of heart rate. The activation of cell signaling pathways involving inhibitory heterotrimeric G proteins acts to slow the heart rate via modulation of ion channels.
Ang, R, Opel, A, Tinker, A
core +1 more source
T-Type Calcium Channels Are Required to Maintain Viability of Neural Progenitor Cells
Biomolecules & Therapeutics, 2018 T-type calcium channels are low voltage-activated calcium channels that evoke small and transient calcium currents. Recently, T-type calcium channels have been implicated in neurodevelopmental disorders such as autism spectrum disorder and neural tube ...
Ji-Woon Kim +10 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Channels, 2023 Missense mutations in the human secretary carrier-associated membrane protein 5 (SCAMP5) cause a variety of neurological disorders including neurodevelopmental delay, epilepsy, and Parkinson’s disease.
Emilio R. Mustafá +2 more
doaj +1 more source
Cellular Calcium Regulation in Hypertension [PDF]
, 2017 In vascular muscle cells, two distinct types of functionally important calcium (Ca2++) channels, called transient (T) and sustained (L), are differentiated by dihydropyridine calcium antagonists (CaA).
Erne, P., Hermsmeyer, K.
core
Calcium in the initiation, progression and as an effector of Alzheimer's disease pathology. [PDF]
, 2009 The cause(s) of sporadic Alzheimer's disease (sAD) are complex and currently poorly understood. They likely result from a combination of genetic, environmental, proteomic and lipidomic factors that crucially occur only in the aged brain.
Green, Kim N
core +1 more source
Amiloride Docking to T-Type Calcium Channels [PDF]
Biophysical Journal, 2011 Amiloride and its analogues are small molecules frequently used as potassium-sparing diuretics. These drugs have been utilized for decades in the treatment of diseases like hypertension. They are known for interacting with the sodium/hydrogen antiporter, sodium/calcium exchanger, and mainly with the epithelial sodium channel (ENaC).
Rivera, Manuel +2 more
openaire +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Ethosuximide inhibits acute histamine- and chloroquine-induced scratching behavior in mice
Molecular Brain, 2021 We have recently reported that the Cav3.2 T-type calcium channel which is well known for its key role in pain signalling, also mediates a critical function in the transmission of itch/pruritus.
Vinicius M. Gadotti, Gerald W. Zamponi
doaj +1 more source