Results 301 to 310 of about 315,989 (337)

Gating a calcium channel [PDF]

Science, 2016
Structural Biology The type 2 ryanodine receptor (RyR2) controls the release of calcium ions from the sarcoplasmic reticulum in cardiac cells—the initiating step in cardiac muscle contraction. Mutations in RyR2 are associated with cardiac diseases. Peng et al.
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Calcium Channel Blockers [PDF]

AACN Advanced Critical Care, 1992
Calcium channel blockers are widely used in the treatment of ischemic heart disease, hypertension, and supraventricular tachycardia. The prototype agents, verapamil, nifedipine, and diltiazem, represent three classes of calcium channel blockers, each of which has different pharmacologic effects.
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Calcium Channels

2008
The SLC4 ( s o l ute c arrier 4) family is a group of a membrane proteins that share sequence homology and in general mediate the transport of bicarbonate. It should be noted that bicarbonate transport is not unique to the SLC4 family. The structurally unrelated SLC26 family has at least three proteins that mediate CI − HCO − 3 exchange.
Joost G. J. Hoenderop, René J. M. Bindels   +1 more
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Calcium channel activation stabilizes a neuronal calcium channel mRNA

Nature Neuroscience, 1999
We have identified a calcium-dependent pathway in neurons that regulates expression levels of the alpha1B subunit and N channel current. When neurons are depolarized and voltage-gated calcium channels activated, the half-life of cellular N channel alpha1B mRNA is prolonged.
Maureen W. McEnery, Seema Gupta, Stephanie Schorge, Zhixin Lin, Zhixin Lin, Diane Lipscombe   +5 more
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Inactivation of calcium channels

Comparative Biochemistry and Physiology Part A: Physiology, 1989
Rapid progress in our understanding of the properties and functions of voltage-gated calcium channels had produced the need for an update to our previous review of calcium inactivation. The major elements of change included in this review are: 1.
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L-type calcium channels and calcium channel ligands

1992
Abstract L-type calcium channels possess high affinity drug binding domains for different chemical classes of calcium channel active drugs. Reversible binding experiments using radiolabeled and fluorescently labeled calcium antagonists revealed tight allosteric coupling between several distinct drug binding domains and divalent cation binding sites ...
Hartmut Glossmann, Jörg Striessnig
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Calcium channel diversity: multiple roles of calcium channel subunits

Current Opinion in Neurobiology, 2009
Until recently we held the simple view that voltage-gated calcium channels consisted of an alpha1 subunit, usually associated with auxiliary beta subunits and alpha(2)delta subunits and that skeletal muscle calcium channels were also associated with a gamma subunit.
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[42] Assay for calcium channels

1985
Publisher Summary This chapter focuses on biochemical assays for Ca 2+ -selective channels in electrically excitable membranes, which are blocked in electrophysiological and pharmacological experiments by verapamil, 1,4-dihydro-pyridines, diltiazem (and various other drugs), as well as inorganic di- or trivalent cations.
Hartmut Glossmann, D. R. Ferry
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Calcium Channels and Calcium-Regulated Channels in Human Red Blood Cells

2019
Free Calcium (Ca2+) is an important and universal signalling entity in all cells, red blood cells included. Although mature mammalian red blood cells are believed to not contain organelles as Ca2+ stores such as the endoplasmic reticulum or mitochondria, a 20,000-fold gradient based on a intracellular Ca2+ concentration of approximately 60 nM vs.
Kaestner, Lars, Bogdanova, Anna, Egee, Stephane   +2 more
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Calcium Channel

Annual Review of Neuroscience, 1981
S, Hagiwara, L, Byerly
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