Results 91 to 100 of about 640,931 (310)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

A Scanning Transmission X-ray Microscopy Study of Cubic and Orthorhombic C₃A and Their Hydration Products in the Presence of Gypsum. [PDF]

, 2016
This paper shows the microstructural differences and phase characterization of pure phases and hydrated products of the cubic and orthorhombic (Na-doped) polymorphs of tricalcium aluminate (C₃A), which are commonly found in traditional Portland cements ...
Chae, Sejung Rosie, Geng, Guoqing, Kirchheim, Ana Paula, Monteiro, Paulo JM, Rheinheimer, Vanessa, Rodríguez, Erich D   +5 more
core   +3 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

4-Oxatricyclo[5.2.1.0^2,6]dec-8-ene-3,5-dione Derivatives as NMDA Receptor- and VGCC Blockers with Neuroprotective Potential

Molecules, 2020
The impact of excitotoxicity mediated by N-methyl-D-aspartate (NMDA) receptor overactivation and voltage gated calcium channel (VGCC) depolarization is prominent among the postulated processes involved in the development of neurodegenerative disorders ...
Ayodeji O. Egunlusi, Sarel F. Malan, Sylvester I. Omoruyi, Okobi E. Ekpo, Jacques Joubert   +4 more
doaj   +1 more source

Beef meat promotion of dimethylhydrazine-induced colorectal carcinogenesis biomarkers is suppressed by dietary calcium [PDF]

, 2007
Red meat consumption is associated with increased risk of colorectal cancer. We have previously shown that haemin, Hb and red meat promote carcinogen-induced preneoplastic lesions: aberrant crypt foci (ACF) and mucin-depleted foci (MDF) in rats.
Corpet, Denis E., Guéraud, Françoise, Pierre, Fabrice, Santarelli, Raphaëlle L., Taché, Sylviane   +4 more
core   +4 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Calcium anacardate as source of phenolic compounds in diet for New Zealand White female rabbits

Pesquisa Agropecuária Brasileira
The objective of this work was to evaluate the effect of the dietary addition of calcium anacardate as a source of phenolic compounds on the reproductive performance and blood antioxidant parameters of New Zealand White female rabbits.
José Vladmir Araujo Oliveira, Pedro Henrique Watanabe, Maurício Francisco Vieira Neto, Germano Augusto Jerônimo do Nascimento, Rafael Carlos Nepomuceno, Paulo Natanael Lima Pacheco, Marcelo Emersom Costa Santos, Ednardo Rodrigues Freitas   +7 more
doaj   +1 more source

Functional characterization and analgesic effects of mixed cannabinoid receptor/T-type channel ligands

Molecular Pain, 2011
Background Both T-type calcium channels and cannabinoid receptors modulate signalling in the primary afferent pain pathway. Here, we investigate the analgesics activities of a series of novel cannabinoid receptor ligands with T-type calcium channel ...
You Haitao, Gadotti Vinicius M, Petrov Ravil R, Zamponi Gerald W, Diaz Philippe   +4 more
doaj   +1 more source

Calcium Permeable Channels in Cancer Hallmarks

Frontiers in Pharmacology, 2020
Cancer, the second cause of death worldwide, is characterized by several common criteria, known as the “cancer hallmarks” such as unrestrained cell proliferation, cell death resistance, angiogenesis, invasion and metastasis.
Sendoa Tajada, Carlos Villalobos
doaj   +1 more source

Inactivation of anandamide signaling : A continuing Debate [PDF]

, 2010
Copyright 2011 Elsevier B.V., All rights reserved.Peer reviewedPublisher ...
Ahluwalia, Ahn, Alexander, Alexander, Beltramo, Bhave, Bifulco, Bisogno, Bisogno, Bosier, Cadas, Chen, Chuang, Clapper, Cravatt, Cravatt, Cristino, Day, De Petrocellis, De Petrocellis, De Petrocellis, Desarnaud, Deutsch, Deutsch, Devane, Devane, Di Carlo, Di Marzo, Di Marzo, Di Marzo, Egertova, Evans, Evans, Evans, Fedorova, Glaser, Guzmán, Hampson, Hanus, Harizi, Hesham Khairy, Hillard, Hillard, Hillard, Horvath, Howlett, Howlett, Iversen, Jarrahian, Jiang, Jonsson, Kaczocha, Kaczocha, Katayama, Kathuria, Khairy, Klein, Koutek, Kulkarni-Narla, Liu, Long, Maccarrone, Malcher-Lopes, Matsuda, McFarland, Mechoulam, Mechoulam, Mechoulam, Mechoulam, Miller, Moore, Mulder, Munro, Numazaki, Okamoto, Ortar, Pertwee, Piomelli, Poling, Porter, Premkumar, Randall, Schlosburg, Schmid, Simon, Stella, Stremmel, Sun, Sun, Sánchez, Thomas, Thors, Tian, Tsou, Tsuboi, Ueda, Ueda, Van den Bossche, Van Der Stelt, Wael E. Houssen, Walker, Weber, Wenger, Wood, Woodward, Yu, Zygmunt   +106 more
core   +3 more sources