RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca2+ assays. [PDF]
, 2020 Elevated cytoplasmic [Ca2+] is characteristic in severe skeletal and cardiac myopathies, diabetes, and neurodegeneration, and partly results from increased Ca2+ leak from sarcoplasmic reticulum stores via dysregulated ryanodine receptor (RyR) channels ...
Bers, Donald M +6 more
core +2 more sources
Marine Drugs, 2022 Nowadays, the use of marine by-products as precursor materials has gained great interest in the extraction and production of chemical compounds with suitable properties and possible pharmaceutical applications.
Magdalena Mititelu +10 more
doaj +1 more source
Regulation of intracellular cyclic GMP concentration by light and calcium in electropermeabilized rod photoreceptors. [PDF]
, 1994 This study examines the regulation of cGMP by illumination and by calcium during signal transduction in vertebrate retinal photoreceptor cells. We employed an electropermeabilized rod outer segment (EP-ROS) preparation which permits perfusion of low ...
Coccia, V J, Cote, Rick H.
core +2 more sources
The Decopperization and Coagulation by Use the Carbon-N-Ox Method
Archives of Metallurgy and Materials, 2017 This paper discusses the impact of complex chemical reagents during the process of decopperisation of slag. The beneficial effect of carbide response factors with the participation of nitrogen was indicated as well as the role of stimulators surfactants.
Bydałek A.W. +3 more
doaj +1 more source
Development of Store-Operated Calcium Entry-Targeted Compounds in Cancer
Frontiers in Pharmacology, 2021 Store-operated Ca2+ entry (SOCE) is the major pathway of Ca2+ entry in mammalian cells, and regulates a variety of cellular functions including proliferation, motility, apoptosis, and death.
Xiaojing Liang +5 more
doaj +1 more source
FSA Neutralization with Calcium Compounds
Procedia Engineering, 2014 AbstractAs environmental regulations continue to restrict chemical processing emissions, phosphate plant operators will eventually be required to neutralize fluoride waste materials. Most phosphate plants currently use direct contact barometric condensers with recirculating cooling pond water that is saturated with fluoride salts. Most of this fluoride
Salah F. Albustami, Stephen W. Hilakosa
openaire +2 more sources
Spongionella secondary metabolites protect mitochondrial function in cortical neurons against oxidative stress [PDF]
, 2014 Accepted: 8 January 2014 This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Acknowledgments
Alfonso, Amparo +9 more
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Electronic band structure and carrier effective mass in calcium aluminates [PDF]
, 2007 First-principles electronic band structure investigations of five compounds of the CaO-Al2O3 family, 3CaO.Al2O3, 12CaO.7Al2O3, CaO.Al2O3, CaO.2Al2O3 and CaO.6Al2O3, as well as CaO and alpha-, theta- and kappa-Al2O3 are performed.
A. C. Tas +15 more
core +3 more sources
Canvass: a crowd-sourced, natural-product screening library for exploring biological space [PDF]
, 2018 NCATS thanks Dingyin Tao for assistance with compound characterization. This research was supported by the Intramural Research Program of the National Center for Advancing Translational Sciences, National Institutes of Health (NIH). R.B.A.
Andrade, Rodrigo B. +94 more
core +1 more source
Comparison of the Effect of MI Varnish (Fluoride Varnish Containing Amorphous Casein Phosphopeptide Calcium Sulfate) and V Varnish (Fluoride Varnish Containing Tricalcium Phosphate and Xylitol) on the Fluoride Uptake of Primary Tooth Enamel [PDF]
Journal of Mashhad Dental SchoolBackground: Identifying fluoride combinations that result in maximum enamel uptake and greater resistance to cariogenic factors is a key concern in preventive dentistry.
Sahar Soleimani +3 more
doaj +1 more source