Results 171 to 180 of about 2,715,719 (363)

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

Calcium and magnesium absorption and retention by growing goats offered diets with different calcium sources [PDF]

open access: yes, 2016
Calcium addition is necessary in order to balance the high phosphorus concentrations that are characteristic of high-concentrate ruminant diets. However, calcium sources differ in their bioavailability. Our objective was to determine apparent calcium and
Caldwell, James D.   +5 more
core   +2 more sources

Computational Modelling of Nonlinear Calcium Waves [PDF]

open access: yesX. S. Yang, Computational modelling of nonlinear calcium waves, Applied Mathematical Modelling, Vol. 30(2), 200-208 (2006)., 2010
The calcium transport in biological systems is modelled as a reaction-diffusion process. Nonlinear calcium waves are then simulated using a stochastic cellular automaton whose rules are derived from the corresponding coupled partial differential equations.
arxiv  

CALCIUM METABOLISM IN A CASE OF GARGOYLISM, STUDIED WITH THE AID OF RADIOCALCIUM1 [PDF]

open access: bronze, 1958
Félix Bronner   +3 more
openalex   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

Efficacy of Ultrasound-guided Radiofrequency Ablation of Parathyroid Hyperplasia: Single Session vs. Two-Session for Effect on Hypocalcemia [PDF]

open access: yes, 2020
To evaluate safety and efficacy of one- vs. two-session radiofrequency ablation (RFA) of parathyroid hyperplasia for patients with secondary hyperparathyroidism (SHPT) and to compare the outcome of both methods on hypocalcemia.
He, Hong-Feng   +7 more
core   +1 more source

Calcium and phosphorus metabolism in broilers: Effect of homeostatic mechanism on calcium and phosphorus digestibility1

open access: yes, 2013
SUMMARY In this paper, we present a review of the current knowledge of calcium and phosphorus metabolism as it relates to homeostatic mechanisms in poultry; contrasts with mammalian systems, as well as information that is available for mammalian systems ...
M. Proszkowiec-Weglarz, Roselina Angel
semanticscholar   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

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