Results 21 to 30 of about 793,657 (289)

Dual Inoculation With Arbuscular Mycorrhizal Fungi and Phosphorus Solubilizing Fungi Synergistically Enhances the Mobilization and Plant Uptake of Phosphorus From Meat and Bone Meal

Frontiers in Soil Science, 2021
Phosphorus (P) is the second most important mineral nutrient for plant growth and plays a vital role in maintaining global food security. The natural phosphorus reserves [phosphate rock (PR)] are declining at an unprecedented rate, which will threaten ...
Bhupinder Singh Jatana, Christopher Kitchens, Christopher Ray, Patrick Gerard, Nishanth Tharayil   +4 more
doaj   +1 more source

α‐adrenergic mobilization of hepatic mitochondrial calcium [PDF]

FEBS Letters, 1979
Recently it has been demonstrated that activation of a-adrenergic receptors by catecholamines in isolated rat liver parenchymal cells causes release of calcium from some intracellular store(s) [l-3] . It has been proposed that the resulting rise in cytosolic calcium is responsible for some of the metabolic changes observed [l-3].
Blackmore, P F, Dehaye, Jean-Paul, Strickland, W G, Exton, J H   +3 more
openaire   +4 more sources

Neuronal expression of the human neuropeptide S receptor NPSR1 identifies NPS-induced calcium signaling pathways.

PLoS ONE, 2015
The neuropeptide S (NPS) system was discovered as a novel neurotransmitter system a decade ago and has since been identified as a key player in the modulation of fear and anxiety.
Frank Erdmann, Sebastian Kügler, Peter Blaesse, Maren D Lange, Boris V Skryabin, Hans-Christian Pape, Kay Jüngling   +6 more
doaj   +1 more source

Extraoral expression and characterization of bitter taste receptors in Astyanax mexicanus (Mexican tetra fish)

FASEB BioAdvances, 2022
The chemical senses of olfaction and taste are well developed in fish and play a vital role in its various activities such as navigation, mate recognition, and food detection.
Vikram Bhatia, Vivianne Cruz deJesus, Feroz Ahmed Shaik, Appalaraju Jaggupilli, Nisha Singh, Prashen Chelikani, Devi Atukorallaya   +6 more
doaj   +1 more source

The Target Residence Time of Antihistamines Determines Their Antagonism of the G Protein-Coupled Histamine H1 Receptor

Frontiers in Pharmacology, 2017
The pharmacodynamics of drug-candidates is often optimized by metrics that describe target binding (Kd or Ki value) or target modulation (IC50). However, these metrics are determined at equilibrium conditions, and consequently information regarding the ...
Reggie Bosma, Gesa Witt, Lea A. I. Vaas, Ivana Josimovic, Philip Gribbon, Henry F. Vischer, Sheraz Gul, Rob Leurs   +7 more
doaj   +1 more source

The Pyrazolyl-Urea Gege3 Inhibits the Activity of ANXA1 in the Angiogenesis Induced by the Pancreatic Cancer Derived EVs

Biomolecules, 2021
The pyrazolyl-urea Gege3 molecule has shown interesting antiangiogenic effects in the tumor contest. Here, we have studied the role of this compound as interfering with endothelial cells activation in response to the paracrine effects of annexin A1 ...
Raffaella Belvedere, Elva Morretta, Nunzia Novizio, Silvana Morello, Olga Bruno, Chiara Brullo, Antonello Petrella   +6 more
doaj   +1 more source

Modulation of BCR Signaling by the Induced Dimerization of Receptor-Associated SYK

Antibodies, 2017
Clustering of the B cell antigen receptor (BCR) by polyvalent antigens is transmitted through the SYK tyrosine kinase to the activation of multiple intracellular pathways that determine the physiological consequences of receptor engagement.
Mark L. Westbroek, Robert L. Geahlen
doaj   +1 more source

Pharmacology of Kappa Opioid Receptors: Novel Assays and Ligands

Frontiers in Pharmacology, 2022
The present study investigated the in vitro pharmacology of the human kappa opioid receptor using multiple assays, including calcium mobilization in cells expressing chimeric G proteins, the dynamic mass redistribution (DMR) label-free assay, and a ...
Chiara Sturaro, Davide Malfacini, Michela Argentieri, Francine M. Djeujo, Erika Marzola, Valentina Albanese, Chiara Ruzza, Chiara Ruzza, Remo Guerrini, Remo Guerrini, Girolamo Calo’, Paola Molinari   +11 more
doaj   +1 more source

New Linear Precursors of cIDPR Derivatives as Stable Analogs of cADPR: A Potent Second Messenger with Ca²⁺-Modulating Activity Isolated from Sea Urchin Eggs

Marine Drugs, 2019
Herein, we report on the synthesis of a small set of linear precursors of an inosine analogue of cyclic ADP-ribose (cADPR), a second messenger involved in Ca2+ mobilization from ryanodine receptor stores firstly isolated from sea urchin eggs extracts ...
Stefano D’Errico, Emy Basso, Andrea Patrizia Falanga, Maria Marzano, Tullio Pozzan, Vincenzo Piccialli, Gennaro Piccialli, Giorgia Oliviero, Nicola Borbone   +8 more
doaj   +1 more source

Age Dependent Changes in Corneal Epithelial Cell Signaling

Frontiers in Cell and Developmental Biology, 2022
The cornea is exposed daily to a number of mechanical stresses including shear stress from tear film and blinking. Over time, these stressors can lead to changes in the extracellular matrix that alter corneal stiffness, cell-substrate structures, and the
Kristen L. Segars, Nicholas A. Azzari, Stephanie Gomez, Cody Machen, Celeste B. Rich, Vickery Trinkaus-Randall, Vickery Trinkaus-Randall   +6 more
doaj   +1 more source