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Significance of Glycosaminoglycans for the Formation of Calcium Oxalate Stones

American Journal of Kidney Diseases, 1991
Glycosaminoglycans (GAG) are polysaccharide chains composed of repeating disaccharides of identical composition. Little is known about the mechanism of their excretion, but there is no doubt that urinary GAGs are degradation products of high molecular weight proteoglycans.
A, Hesse, H, Wuzel, W, Vahlensieck
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Observations on Calcium Oxalate Stone Formers

British Journal of Urology, 1992
Summary Biochemical studies were performed on 22 adult patients with idiopathic recurrent calcium oxalate renal stone disease and 23 healthy controls. It was found that urinary glutamic‐oxaloacetic acid transaminase (UGOT) and urinary glutamic‐pyruvic acid transaminase (UGPT) activity was low and lactate ...
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Submicroscopic Investigations on Calcium Oxalate Stone Genesis

European Urology, 1979
Scanning electron microscopy of calcium oxalate stones indicates a zonary structure of the Weddellite crystals of urine concrements which is due to concentration-dependent growth oscillations representing the precipitation of various calcium oxalate hydrates.
W, Berg   +3 more
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Microorganisms and Calcium Oxalate Stone Disease

Nephron Physiology, 2004
Microorganisms may have a role in the pathogenesis and prevention of kidney stones. The subjects of this review include nanobacteria, <i>Oxalobacter formigenes</i>, and lactic acid bacteria. Not reviewed here is the well-described role of infections of the urinary tract with <i>Proteus</i> species and other urease-producing ...
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Genetic Factors in Calcium Oxalate Stone Disease

Journal of Urology, 1995
Idiopathic calcium oxalate nephrolithiasis is a complex, multifactorial disease resulting from an interaction between environmental and genetic factors. Urinary characteristics often associated with the disease include hypercalciuria, hyperoxaluria, hypocitraturia and hyperuricosuria. Roles have also been suggested for glycosaminoglycans, magnesium and
H O, Goodman, R P, Holmes, D G, Assimos
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Studies on crystalluria in calcium oxalate stone formers

Urological Research, 1984
The excretion of calcium oxalate and calcium phosphate crystals was studied in fractionated 24 h urine from 7 men with recurrent calcium oxalate stone disease, both before and during daily administration of 5 mg bendroflumethiazide. Urinary calcium, oxalate, magnesium, citrate, phosphate, pH, and inhibition of calcium oxalate crystal growth rate were ...
C, Ahlstrand, H G, Tiselius, L, Larsson
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Intracellular Events in the Initiation of Calcium Oxalate Stones

Nephron Experimental Nephrology, 2004
This review summarizes our current understanding of intracellular events in the initiation of kidney stone formation, focusing on results from studies using renal epithelial cells in vitro. Such studies have shown that oxalate – either in crystalline or in soluble form – triggers a spectrum of responses in renal cells that favor stone formation ...
Julie A, Jonassen   +3 more
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Dietary calcium, calcium supplements, and the risk of calcium oxalate kidney stones

American Journal of Health-System Pharmacy, 2006
Kidney stones are concentrated masses of crystallized substances, such as calcium, oxalate, or uric acid, that are excreted by the kidneys into the urine. The formation of calcium oxalate stones depends on the level of urinary supersaturation with calcium and oxalate.
Melissa J, Baker, Daniel S, Longyhore
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Conversion of Calcium Oxalate to Calcium Phosphate With Recurrent Stone Episodes

Journal of Urology, 2003
We have extended our previous observation that the percent occurrence of calcium oxalate stones decreased while that of calcium phosphate stones increased with each new stone event.The National VA Crystal Identification Center has analyzed veteran patient urinary tract stones from VA hospitals throughout the United States since 1983.
Neil, Mandel   +4 more
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Kidney Models of Calcium Oxalate Stone Formation

Nephron Physiology, 2004
This review compares and contrasts three mathematical models used to describe the flow of urine through the renal tubule and the composition of tubular fluid throughout the length of the nephron. From these data the relative supersaturation of tubular fluid with respect to calcium oxalate (CaOx) is calculated at various points along the tubule.
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