Results 41 to 50 of about 1,131,166 (283)

Application of Calcium Phosphate Materials in Dentistry

International Journal of Biomaterials, 2013
Calcium phosphate materials are similar to bone in composition and in having bioactive and osteoconductive properties. Calcium phosphate materials in different forms, as cements, composites, and coatings, are used in many medical and dental applications.
Jabr S. Al-Sanabani, Ahmed A. Madfa, Fadhel A. Al-Sanabani   +2 more
doaj   +1 more source

Remote eradication of delayed infection on orthopedic implants via magnesium-based total morphosynthesis of biomimetic mineralization strategy

Materials & Design, 2023
Orthopedic delayed and late infections are devastating afflictions for patients who have undergone implantation. Even though versatile antibacterial modification on medical devices brought the hope of eradicating pathogenic bacteria.
Yikai Wang, Zhongru Gou, Siyuan Ma, Zhihui Jin, Sen Chen, Jia Ye, Zhigang Nie, Zhihui Wan, Chongda Zhang, Yuxiao Ye, Xiaohua Yu, Zhaoming Ye, Yijun Ren   +12 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Bioactivity enhancement by Sr doped Zn-Ca-P coatings on biomedical magnesium alloy

Journal of Magnesium and Alloys, 2019
The effect of strontium doped Zn-Ca-P (ZCP) coating by chemical conversion technique on the biodegradation of AZ31 alloy was evaluated. The coating formed with 1.5 wt.% Sr and 20 min phosphating time at 50 °C with pH 2.5 completely covers the alloy ...
P. Amaravathy, T.S. Sampath Kumar
doaj   +1 more source

Amorphous calcium phosphate, the lack of order is an abundance of possibilities

Biomaterials and Biosystems, 2022
For almost three decades from its discovery, amorphous calcium phosphate (ACP) was not considered a suitable biomaterial due to its structural instability.
Lorenzo Degli Esposti, Michele Iafisco
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Hybrid calcium phosphate coatings for implants [PDF]

AIP Conference Proceedings, 2016
Monophasic biomaterials cannot provide all the necessary functions of bones or other calcined tissues. It is necessary to create for cancer patients the multiphase materials with the structure and composition simulating the natural bone. Such materials are classified as hybrid, obtained by a combination of chemically different components.
Malchikhina, Alena Igorevna, Shesterikov, Evgeny Viktorovich, Bolbasov, Evgeny Nikolaevich, Ignatov, Viktor Pavlovich, Tverdokhlebov, Sergei Ivanovich   +4 more
openaire   +2 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Calcium phosphate ceramic coatings as carriers of vancomycin

Biomaterials, 1997
Infection in the setting of total joint arthroplasty remains a challenging problem. Attention has turned to developing methods of local delivery of antibiotics for prophylaxis. Vancomycin loaded into calcium phosphate ceramic coatings on titanium alloy substrates is a clinically relevant concept in the setting of total joint arthroplasty.
S, Radin, J T, Campbell, P, Ducheyne, J M, Cuckler   +3 more
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source