Results 51 to 60 of about 45,846 (301)

Bioactive sphene-based ceramic coatings on cpTi substrates for dental implants: An in vitro study [PDF]

, 2018
Titanium implant surface modifications have been widely investigated to favor the process of osseointegration. The present work aimed to evaluate the effect of sphene (CaTiSiO5) biocoating, on titanium substrates, on the in vitro osteogenic ...
Badocco, Denis, Biasetto, Lisa, Brunello, Giulia, Elsayed, Hamada, Ferroni, Letizia, Gardin, Chiara, Pastore, Paolo, Sivolella, Stefano, Zavan, Barbara   +8 more
core   +2 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Biomimetic fabrication of calcium phosphate/chitosan nanohybrid composite in modified simulated body fluids

eXPRESS Polymer Letters, 2017
In this study, nucleation and growth of bone-like hydroxyapatite (HAp) mineral in modified simulated body fluids (m-SBF) were induced on chitosan (CS) substrates, which were prepared by spin coating of chitosan on Ti substrate.
K. H. Park, S. J. Kim, M. J. Hwang, H. J. Song, Y. J. Park   +4 more
doaj   +1 more source

Characterisation of calcium phosphate/titanium dioxide hybrid coatings [PDF]

Journal of Materials Science: Materials in Medicine, 2007
The role of titanium dioxide (TiO2) as a means to engender enhanced stability into calcium phosphate (Ca-P) coatings has been well recognised. Several different methods have been used to create such Ca-P/TiO2 hybrid layers on a range of substrates.
A R, Boyd, G A, Burke, H, Duffy, M L, Cairns, P, O'Hare, B J, Meenan   +5 more
openaire   +2 more sources

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Poly(alkyl methacrylate) tooth coatings for dental care: evaluation of the demineralisation-protection benefit using a time-resolved in vitro method [PDF]

, 2011
An in vitro method for the time-resolved quantification of acid-mediated tooth demineralisation has been developed and evaluated against putative non-permanent protective formulations based on a series of poly(alkyl methacrylate)s.
Attin, Barbour, Barbour, Birthe V. Nielsen, Chen, Churchley, Clarkson, Diarra, El Aidi, Esser, Eugen Barbu, Finke, Ganss, Ganss, Garberoglio, Gareth D. Rees, Hannig, Hannig, Hara, Hara, Hicks, Hughes, Jaeggi, James R. Smith, John Tsibouklis, Ketterl, Koulourides, Magalhães, Mason, Mason, Mavropoulos, Mellberg, Meurman, Moss, Nekrashevych, Nielsen, Nikcevic, Nunn, Petersson, Pleshko, Reich, Shellis, Sun, Tagami, ten Cate, Thomas G. Nevell, Venasakulchai, Wulf   +47 more
core   +4 more sources

Long-Term Assessment of the In Vitro Corrosion Resistance of Biomimetic ACP Coatings Electrodeposited from an Acetate Bath

Journal of Functional Biomaterials, 2021
Calcium phosphate coatings are able to improve the osseointegration process due to their chemical composition, which is similar to that of bone tissues.
Patrycja Osak, Joanna Maszybrocka, Julian Kubisztal, Patryk Ratajczak, Bożena Łosiewicz   +4 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Functionalisation of Ti6Al4V and hydroxyapatite surfaces with combined peptides based on KKLPDA and EEEEEEEE peptides [PDF]

, 2017
Surface modifications are usually performed on titanium alloys to improve osteo-integration and surface bioactivity. Modifications such as alkaline and acid etching, or coating with bioactive materials such as hydroxyapatite, have previously been ...
Ben-Nissan, Besim, Bowen, James, Grossin, David, Melo Rodriguez, Gabriela, Stamboulis, Artemis   +4 more
core   +6 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source