Results 61 to 70 of about 14,120 (298)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Nanoparticulate hydroxyapatite and calcium-based CO2 sorbents [PDF]

, 2012
This thesis is focused on the development of synthesis and characterisation protocols for two different nanoparticulate materials; hydroxyapatite (HA), a biomaterial well recognised as chemically akin to human bone, and CaO, a material often used for the
Bilton, Matthew William
core  

Dialysis Preparation of Smart Redox and Acidity Dual Responsive Tea Polyphenol Functionalized Calcium Phosphate Nanospheres as Anticancer Drug Carriers

Molecules, 2020
Large-scale preparation of biocompatible drug delivery systems with targeted recognition and controlled release properties has always been attractive. However, this strategy has been constrained by a lot of design challenges, such as complicated steps ...
Xiuli Ren, Peng Zhang, Zhenhua Chen
doaj   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

A new simplified calcifying solution to synthesize calcium phosphate coatings

, 2013
In this work we set up new experimental conditions to deposit biomimetic coatings of different calcium phosphates onto titanium (Ti) substrates using over-simplified, economically convenient, slightly supersaturated solutions.
BIGI, ADRIANA, BRACCI, BARBARA, PANZAVOLTA, SILVIA   +2 more
core   +1 more source

Ion-Doped Calcium Phosphate-Based Coatings with Antibacterial Properties

Journal of Functional Biomaterials, 2023
Ion-substituted calcium phosphate (CP) coatings have been extensively studied as promising materials for biomedical implants due to their ability to enhance biocompatibility, osteoconductivity, and bone formation. This systematic review aims to provide a
Marco Fosca, Alexandru Streza, Iulian V. Antoniac, Gianluca Vadalà, Julietta V. Rau   +4 more
doaj   +1 more source

Comparative characteristics of osseointegration processes of the calcium phosphate coating implants and implants with germanium enriched calcium phosphate coatings

N.N. Priorov Journal of Traumatology and Orthopedics, 2017
Introduction. Osseointegration process exerts considerable influence on the term of biological fixation of the implants and is an important parameter that is to be focused on at the implant placement. Purpose: to conduct a comparative analysis of the osseointegration of the titanium alloy implants with different coatings for the determination of the ...
E. A. Zelichenko, V. V. Guzeev, Ya. B. Koval’skaya, O. A. Gurova, T. I. Guzeeva   +4 more
openaire   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

The porosity and roughness of electrodeposited calcium phosphate coatings in simulated body fluid [PDF]

Journal of the Serbian Chemical Society, 2015
Calcium phosphate coatings were electrochemically deposited on titanium from the aqueous solution of Ca(NO3)2 and NH4H2PO4 with the current density of 10 mA cm-2 for deposition time of 15 min.
Đošić Marija S., Mitrić Miodrag, Mišković-Stanković Vesna B.   +2 more
doaj   +1 more source