Results 51 to 60 of about 2,920 (197)

Cardiovascular risk factors in patients with calcium pyrophosphate crystal deposition disease

Научно-практическая ревматология, 2019
Calcium pyrophosphate  crystal deposition disease (CPCDD) is among the most common  inflammatory rheumatic diseases; however, studies of cardiovascular risks in CPCDD have not been conducted.Objective: to stratify a cardiovascular risk in patients with ...
M. S. Eliseev, O. V. Zhelyabina, M. N. Chikina, A. M. Novikova   +3 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, Volume 600, Issue 11, Page 1621-1637, June 2026.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

USE OF METHOTREXATE IN PATIENTS WITH CALCIUM PYROPHOSPHATE CRYSTAL DEPOSITION DISEASE

Научно-практическая ревматология, 2018
Objective: to compare the efficacy of methotrexate (MTX) and colchicine in patients with chronic arthritis in calcium pyrophosphate crystal deposition disease (CPPDD).Subjects and methods.
M. S. Eliseev, S. A. Vladimirov, E. L. Nasonov   +2 more
doaj   +1 more source

Advanced imaging techniques in crystal arthritis

Therapeutic Advances in Musculoskeletal Disease
Gout and calcium pyrophosphate deposition (CPPD) disease are the most common causes of crystal arthritis. Identifying the pathogenic crystal deposition is the cornerstone of the diagnosis, but also prognosis and monitoring of the diseases.
Victor Laurent, Georgios Filippou, Silvia Sirotti, Tristan Pascart   +3 more
doaj   +1 more source

Myeloid HDAC7 drives liver inflammation and systemic glucose dysregulation during diet‐induced obesity

Clinical &Translational Immunology, Volume 15, Issue 6, 2026.
This study explored the role of the class IIa histone deacetylase HDAC7 in hepatic inflammation and metabolic disease. Genetic approaches in mice revealed that myeloid HDAC7 drives hepatic inflammation and gene signatures associated with advanced chronic liver disease.
Yizhuo Wang, Divya Ramnath, Kaustav Das Gupta, P Prakrithi, Kavita Bisht, Gregory C Miller, Zherui Xiong, Yujun Wan, Ellen N Tejo, James EB Curson, Rishika Abrol, Sahar Keshvari, Kimberley S Gunther, Jordan D Atkinson, Zhixuan Loh, Jessica A Engel, Christian R Engwerda, Sabrina Sofia Burgener, Kate Schroder, David P Fairlie, Andrew D Clouston, Elizabeth E Powell, Katharine M Irvine, Mitchell A Sullivan, Jean‐Pierre Lévesque, Quan Nguyen, Matthew J Sweet, Denuja Karunakaran   +27 more
wiley   +1 more source

CPPD—differential diagnostics and differential therapeutic challenges [PDF]

Exploration of Musculoskeletal Diseases
Calcium pyrophosphate deposition disease (CPPD), characterized by the presence of calcium pyrophosphate crystals in and around joints, poses diagnostic and therapeutic challenges in rheumatology.
Maria L. Voulgari, Herbert Kellner
doaj   +1 more source

Vascular Calcification: Mechanisms, Models, and Therapies

iNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu, Shu Yang, Ziyi Chen, Xiaoxiao Yang, Zhen Liang, Yuanli Chen   +5 more
wiley   +1 more source

Seropositive Rheumatoid Arthritis Emerging During Acute Phase of Lung Abscess: A Case Report

Respirology Case Reports, Volume 14, Issue 5, May 2026.
We report a rare case of seropositive rheumatoid arthritis (RA) that became clinically apparent during the acute phase of lung infection. This case demonstrates that RA can be diagnosed during the acute course of a respiratory infection and highlights the diagnostic value of rheumatoid factor and anti‐citrullinated protein antibodies testing when new ...
Yusuke Arai, Hiromu Tanaka, Kazuoto Hiramoto, Aina Nomura, Takahiro Asami, Takashi Inoue   +5 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, Volume 20, Issue 4, Page 1041-1060, April 2026.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Calcium Pyrophosphate and Basic Calcium Phosphate Deposition Diseases: The Year in Review 2022

, 2023
Calcium-containing crystal deposition diseases are a common cause of pain and disability but remain relatively under-investigated. No drug has been identified that can prevent deposition or effect dissolution of either calcium pyrophosphate (CPP) or ...
Geraldine Mary McCarthy
core   +1 more source