Results 61 to 70 of about 2,920 (197)

Disease-Associated Particulates and Joint Inflammation; Mechanistic Insights and Potential Therapeutic Targets

Frontiers in Immunology, 2018
It is now well established that intra-articular deposition of endogenous particulates, such as osteoarthritis-associated basic calcium phosphate crystals, gout-associated monosodium urate crystals, and calcium deposition disease-associated calcium ...
Olwyn R. Mahon, Aisling Dunne
doaj   +1 more source

Genetic factors in the pathogenesis of CPPD crystal deposition disease

, 2007
Crystal deposition is a very complex process ruled by numerous factors. A small but important proportion of cases of chondrocalcinosis are monogenic, and many of the genes involved have been identified. These genetic findings strongly point to control of
Brown, M.A., Brown M.A., Couto, A. R., Couto A.R.   +3 more
core   +1 more source

Cobalt‐Doped Biphasic Calcium Phosphate Orchestrates Osteogenesis‐Angiogenesis Signals via Hypoxia‐Mimetic Signaling

Journal of Biomedical Materials Research Part A, Volume 114, Issue 4, April 2026.
ABSTRACT We engineered a cobalt‐doped biphasic calcium phosphate (CoBCP) by combining monetite‐derived pyrophosphate and β‐tricalcium phosphate (β‐TCP) with lattice‐incorporated Co2+, and evaluated its physicochemical profile and in vitro bioactivity relevant to bone regeneration.
Luísa Camilo Suter, Gerson Santos de Almeida, Matheus Luquirini Penteado dos Santos, Maria Gabriela Jacheto Carra, Marcel Rodrigues Ferreira, Margarida Juri Saeki, Willian Fernando Zambuzzi   +6 more
wiley   +1 more source

Cryo‐EM Structures of Alcohol Oxidase Isozymes Reveal Structural Determinants of Cofactor Variation and Enzymatic Activity in Ogataea methanolica

Microbial Biotechnology, Volume 19, Issue 4, April 2026.
The methylotrophic yeast, Ogataea methanolica uniquely harbours two alcohol oxidase (AOD) isozymes, Mod1p and Mod2p, which exhibit distinct kinetic properties and are differentially regulated by methanol and oxygen availability, enabling metabolic adaptation to fluctuating environments.
Hao‐Liang Cai, Atsuhiro Shimada, Tasuku Hamaguchi, Akira Mizoguchi, Koji Yonekura, Kyohei Tsuchiyama, Masaya Shimada, Akio Ebihara, Kazutoshi Tani, Tomoyuki Nakagawa   +9 more
wiley   +1 more source

Sintering Improves the Mechanical Properties of Fluorapatite Scaffolds With Open Porous Gyroid Architecture

International Journal of Applied Ceramic Technology, Volume 23, Issue 2, April 2026.
ABSTRACT Synthetic scaffolds are needed to overcome the limitations of autografts and allografts for the treatment of critical‐sized bone defects. However, fabricating scaffolds with both high porosity and adequate mechanical stability for load‐bearing applications is difficult.
Clark Nielson, Jill Shea, Jayant Agarwal, Sujee Jeyapalina   +3 more
wiley   +1 more source

Ultrasound findings of calcium pyrophosphate deposition disease at metacarpophalangeal joints

, 2022
Objective: To explore the spectrum of articular and peri-articular ultrasound (US) findings at metacarpophalangeal (MCP) joints in calcium pyrophosphate (CPP) deposition disease (CPPD). Methods: Consecutive CPPD patients (chronic CPP crystal inflammatory
Di Matteo, Andrea, Di Battista, Jacopo, Abhishek, Abhishek, Smerilli, Gianluca, Grassi, Walter, Cipolletta, Edoardo, Di Carlo, Marco, Filippucci, Emilio   +7 more
core   +1 more source

Disulfide Crosslinking Induces Rapid Degradation of Arc/Arg3.1 via Hsp70‐Mediated Ubiquitin Ligase Pathway

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Heat shock induces Arc/Arg3.1 Cys34‐Cys159 disulfide crosslinking, promoting oligomerization and Hsp70‐CHIP‐dependent ubiquitination followed by proteasomal degradation during recovery. Disrupting disulfide formation (C159A) impairs CHIP‐mediated ubiquitination and stabilizes Arc/Arg3.1, whereas HSF1 loss limits inducible Hsp70 and leads to Arc ...
Dami So, In‐Kang Song, Yeon Jung Kim, Yeonjoo Lee, Yeon Seung Park, Hee‐Jung Kim, Kong‐Joo Lee, Eun Joo Song   +7 more
wiley   +1 more source

Cervicothoracic intradural intramedullary deposition of calcium pyrophosphate dihydrate crystal: a tumor-mimicking lesion, case report and literature review

Egyptian Journal of Neurosurgery
Background Calcium pyrophosphate deposition (CPPD) disease usually affects peripheral joints in older adults, whereas spinal involvement is rare and intramedullary cases have not been reported.
Karim Gaber, Nadja Pühl, Christoph Sippl, Stefan Linsler, Safwan Saffour   +4 more
doaj   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, Volume 16, Issue 3, Page 474-486, March 2026.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Calcium Pyrophosphate Deposition Disease of the Temporomandibular Joint*

Journal of Neurological Surgery Reports, 2012
Calcium pyrophosphate dihydrate deposition disease (CPDD, tophaceous pseudogout) is a rare crystal arthropathy characterized by calcium pyrophosphate crystal deposition in joint spaces, episodes of synovitis, and radiological features of ...
Vasisht Srinivasan, Andrew Wensel, Paul Dutcher, Shawn Newlands, Mahlon Johnson, George Edward Vates   +5 more
doaj   +1 more source