Results 261 to 270 of about 773,041 (378)

Isotope and archaeobotanical analysis reveal radical changes in mobility, diet and inequalities around 1500 BCE at the core of Europe. [PDF]

Sci Rep
Cavazzuti C, Horváth A, Gémes A, Fülöp K, Szeniczey T, Tarbay JG, McCall A, Rubio BG, Vicze M, Bárány A, Pető Á, Magyari EK, Darabos G, Futó I, Lisztes-Szabó Z, Molnár E, Novak M, Gál E, Fischl KP, Kulcsár G, Szeverényi V, Szabó G, Mester E, Dani J, Palcsu L, Kiss V, Major I, Hajdu T.   +27 more
europepmc   +1 more source

A Study of Skeletal Stem Cell Dynamics and Its Potential Applications in the Design of a Titanium Implant for Senile Osteoporosis

Advanced Science, EarlyView.
Senescent mesenchymal stromal cells (MSCs) drive age‐related osteoporosis (A‐OP) via adipogenic bias. Resveratrol, selected from transcriptome‐identified core genes, is delivered locally using GelMA‐chitosan hydrogel‐functionalised titanium implants. In A‐OP microenvironments, the hydrogel enables the sustained release of resveratrol, which reverses ...
Wuzhe Fan, Tao Zheng, Mingsong Mao, Pengfei Gao, Yulu Yang, Rong Wang, Yao Yang, Yangpeng Zuo, Tiantian Yuan, Ruqing Bai, Weihu Yang, Xingchen Yan, Kaiyong Cai   +12 more
wiley   +1 more source

Insights into periodontal disease: comparative analysis of animal models. [PDF]

Front Dent Med
Barik B, Chawla S, Satapathy BS, Pattanik SK, Kumar JA, Al-Farraj S, Pattnaik G, Sillanpää M.   +7 more
europepmc   +1 more source

Anthocyanins Prevent Mastitis Exacerbation by Inhibiting PANoptosis Activation

Advanced Science, EarlyView.
PANoptosis activation is an effective therapeutic target during mastitis progression, and Gasdermin D activation is key factor contributing to blood milk barrier damage during mastitis, while cyanidin 3‐O‐galactoside can inhibit these targets to exert a protective effect. Therefore, the extraction of key active ingredients from plants for the treatment
Rui Feng, Lin Guo, Fan Wang, Qian Zhang, Guoyan Wang, Hefei Huang, Wei Du, Hong An, Yue Yang, Henghui Miao, Peng Zheng, Tingting Chu, Dengke Zhang, Xiaoxue Yan, Xiaoyu Mi, Qian Ma, Weilin Gao, Yushan Li, Song Li, Yong Zhang, Zhenliang Zhu, Yu Wang, Jun Liu, Xu Liu   +23 more
wiley   +1 more source

The Association Between Periodontal Status, Oral Health-Related Quality of Life and Self-Rated Oral Health in Socially Underprivileged Adolescents. [PDF]

Community Dent Oral Epidemiol
Ripardo ACG, Queiroz AC, Herkrath APCQ, Herkrath FJ, Rebelo Vieira JM, Pereira JV, Rebelo MAB, Vettore MV.   +7 more
europepmc   +1 more source

Mitochondria‐Targeted ROS Scavenging Natural Enzyme Cascade Nanogels for Periodontitis Treatment via Hypoxia Alleviation and Immunomodulation

Advanced Science, EarlyView.
TPP‐SAT, a mitochondria‐targeted natural enzyme‐cascade nanogel, selectively scavenges mitochondrial ROS (e.g., H2O2/·O2⁻) and converts them into therapeutic O2 via enzymatic cascades, alleviating hypoxia and inflammation. It rebalances M1/M2 macrophage polarization, activates the Nrf2 pathway while suppressing NF‐κB, enhances antioxidant defenses, and
Yanfen Zheng, Liuzhou Mao, Qi Wang, Haohua Hu, Bahriman Xarpidin, Zheng Luo, Yun‐Long Wu   +6 more
wiley   +1 more source

Postbiotic <i>Lactiplantibacillus plantarum</i> CECT 9161 Influences the Canine Oral Metagenome and Reduces Plaque Biofilm Formation. [PDF]

Animals (Basel)
Florit-Ruiz A, Rago L, Rojas A, Guzelkhanova B, Pont-Beltran A, Lamelas A, Solaz-Fuster MC, Martinez-Blanch JF, López ME, García-Lainez G, Rosier BT, Day R, Rubio T, Batchelor R, Nixon SL.   +14 more
europepmc   +1 more source

Nature‐Inspired Nanostructures from Multiple‐Species Biomembranes: Rational Engineering and Therapeutic Applications in Tumor‐Targeted Nanomedicine

Advanced Science, EarlyView.
Naturally derived biomembrane nanostructures by mimicking evolutionarily optimized biological architectures could effectively suppress tumor growth and have emerged as a compelling strategy in translational biomedicine. This review provides a systematic overview of rational design and underlying antitumor therapeutic mechanisms of mammalian cells ...
Xiaodan Wei, Chi Wang, Xiangyan Chen, Yuanyuan Zhu, Mei Yang, Ningxi Li, Honglin Huang, Guangjian Zhang, Mingzhen Zhang, Yiyao Liu, Rui Gao   +10 more
wiley   +1 more source

Periodontal Disease in Dogs From Mexico: Description of Most Commonly Affected Teeth and Associated Factors. [PDF]

Vet Med Int
Villegas-Ferre AG, Gutierrez-Blanco E, Martínez-Aguilar VM, Hernandez-Chan GS, Jiménez-Coello M, Ortega-Pacheco A.   +5 more
europepmc   +1 more source

FOXM1 Protects Against Myocardial Ischemia‐Reperfusion Injury in Rodent and Porcine Models by Suppressing MKRN1‐Dependent LKB1 Ubiquitination

Advanced Science, EarlyView.
FOXM1 maintains mitochondrial bioenergetic function by inhibiting MKRN1‐mediated ubiquitination of LKB1 in cardiomyocytes. Loss of FOXM1 in cardiomyocytes results in upregulation of MKRN1, which enhances LKB1 ubiquitination and disrupts AMPK signaling and energy metabolism pathways. Conversely, FOXM1 overexpression preserves mitochondrial bioenergetics
Shuai Song, Xiaokai Zhang, Zihang Huang, Zhiqiang Pei, Linqi Zeng, Fengze Cai, Tongyao Wang, Mohan Li, Chenyan Liu, Yining Song, Jiahao Guo, Hao Lu, Xinyu Weng, Li Shen, Xiaochun Zhang, Xingxing Cai, Aijun Sun, Junbo Ge   +17 more
wiley   +1 more source