Results 41 to 50 of about 422,906 (307)

Core microbe Bifidobacterium in the hindgut of calves improves the growth phenotype of young hosts by regulating microbial functions and host metabolism

Microbiome
Background The growth and health of young ruminants are regulated by their gut microbiome, which can have lifelong consequences. Compared with subjective grouping, phenotypic clustering might be a more comprehensive approach to revealing the relationship
Yimin Zhuang, Duo Gao, Wen Jiang, Yiming Xu, Guanglei Liu, Guobin Hou, Tianyu Chen, Shangru Li, Siyuan Zhang, Shuai Liu, Jingjun Wang, Jianxin Xiao, Mengmeng Li, Wei Wang, Shengli Li, Zhijun Cao   +15 more
doaj   +1 more source

Effects of preweaning calf daily gain and feed intake on first-lactation performance: A meta-analysis

Journal of Dairy Science
: This study aimed to investigate the effects of daily weight gain and feed intake of calves on first-lactation milk yield and composition using a meta-analysis. A total of 57 treatments from 18 studies were included in the study.
Wen Jiang, Jingjun Wang, Shangru Li, Shuai Liu, Yimin Zhuang, Shengli Li, Wei Wang, Yajing Wang, Hongjian Yang, Wei Shao, Zhijun Cao   +10 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Maternal gastrointestinal microbiome shapes gut microbial function and resistome of newborns in a cow-to-calf model

Microbiome
Background The maternal gut microbiome is the direct and important source of early colonization and development of the neonatal gut microbiome. However, differences in unique and shared features between mothers with different physiological phenotypes and
Yimin Zhuang, Shuai Liu, Duo Gao, Yiming Xu, Wen Jiang, Guobin Hou, Sumin Li, Xinjie Zhao, Tianyu Chen, Shangru Li, Siyuan Zhang, Yanting Huang, Jingjun Wang, Jianxin Xiao, Mengmeng Li, Wei Wang, Shengli Li, Zhijun Cao   +17 more
doaj   +1 more source

An investigation of dairy calf management practices, colostrum quality, failure of transfer of passive immunity, and occurrence of enteropathogens among Australian dairy farms

Journal of Dairy Science, 2019
Calf preweaning morbidity and mortality risks have been reported as high in several countries, with average values approximating 35 and 7%, respectively. However, limited data are available for calf morbidity and mortality risks on Australian dairy farms.
A. Abuelo, Peter Havrlant, Natalie Wood, M. Hernandez-Jover   +3 more
semanticscholar   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Contribution to knowledge of colostral immunoglobulin absorption in intensively bred calves [PDF]

Veterinarski Glasnik, 2007
A whole series of factors affect the degree of absorption of colostral immunolobulins. One of the most important factors is the time of feeding of newborn calves with colostrums in the first hours following birth.
Jonić Branko, Mirilović Milorad
doaj   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

MicroRNA‐microbiota interactions: Emerging strategies for modulating intestinal homeostasis and enhancing host health

iMetaOmics
Long‐term artificial selection and environmental shifts have driven adaptive changes in both the host genome and the intestinal microbiota. The complex symbiotic relationship between these two has become essential for maintaining intestinal homeostasis ...
Tianle He, Jiaying Ma, Shuai Liu, Boyan Ma, Jingtao You, Jingjun Wang, Mengmeng Li, Wei Wang, Ya Jing Wang, Shengli Li, Zhijun Cao   +10 more
doaj   +1 more source