Results 51 to 60 of about 2,301,131 (278)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

High Accuracy Solar Diffuser BRDF Measurement for On-Board Calibration in the Solar Reflective Band

Remote Sensing, 2023
In the solar reflective band, an on-board calibration method based on a solar diffuser (SD) can realize full aperture, full field of view, and end-to-end absolute radiometric calibration of optical remote sensors.
Zhiyuan Zhang, Hongyao Chen, Wenxin Huang, Xiaobing Zheng, Liming Zhang   +4 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Dynamic Bayesian Nonlinear Calibration [PDF]

, 2014
Statistical calibration where the curve is nonlinear is important in many areas, such as analytical chemistry and radiometry. Especially in radiometry, instrument characteristics change over time, thus calibration is a process that must be conducted as ...
Boone, Edward L., Rivers, Derick L.
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Space temperature traceability based on near-site transfer of miniature fixed points

Communications Engineering
Long-term remote sensing precision depends on real-time radiation calibration, challenging the stability and accuracy of spaceborne calibrators in harsh space environments.
Ruiheng Sima, Xiaopeng Hao, Jian Song, Ling Ling, Jingjing Zhou, Hong Qi, Mingjian Gu, Lei Ding   +7 more
doaj   +1 more source

Reconstructing the calibrated strain signal in the Advanced LIGO detectors [PDF]

, 2018
Advanced LIGO's raw detector output needs to be calibrated to compute dimensionless strain h(t). Calibrated strain data is produced in the time domain using both a low-latency, online procedure and a high-latency, offline procedure.
Betzwieser, J., Brown, Duncan A., Burguet-Castell, J., Cahillane, C., Goetz, E., Izumi, K., Kandhasamy, S., Karki, S., Kissel, J. S., Mendell, G., Savage, R. L., Siemens, X., Tuyenbayev, D., Urban, A. L., Viets, A. D., Wade, M., Weinstein, A. J.   +16 more
core   +2 more sources

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Study of the Application of FY-3D/MERSI-II Far-Infrared Data in Wildfire Monitoring

Remote Sensing, 2023
In general, the far-infrared channel in the wavelength range of 10.5–12.0 µm plays an auxiliary role in wildfire detection as its sensitivity to high-temperature targets is far lower than the mid-infrared channel in the wavelength range of 3.5–4.0 µm at ...
Wei Zheng, Jie Chen, Cheng Liu, Tianchan Shan, Hua Yan   +4 more
doaj   +1 more source