Results 51 to 60 of about 1,314,320 (308)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Hemodynamic monitoring: To calibrate or not to calibrate? Part 2 — Non-calibrated techniques [PDF]

Anestezjologia Intensywna Terapia, 2015
There is much evidence that fluid overload leads to adverse outcomes in perioperative and critically ill patients. Cardiac output monitoring can help us guiding initial and ongoing fluid resuscitation and can help us to assess whether a patient will be responsive to fluids when hypotensive.
Bernards, J., Mekeirele, M., Hoffmann, Britta, Peeters, Y., De Raes, M., Malbrain, M.L.N.G.   +5 more
openaire   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Space temperature traceability based on near-site transfer of miniature fixed points

Communications Engineering
Long-term remote sensing precision depends on real-time radiation calibration, challenging the stability and accuracy of spaceborne calibrators in harsh space environments.
Ruiheng Sima, Xiaopeng Hao, Jian Song, Ling Ling, Jingjing Zhou, Hong Qi, Mingjian Gu, Lei Ding   +7 more
doaj   +1 more source

High-Precision Automatic Calibration Modeling of Point Light Source Tracking Systems

Sensors, 2021
To realize high-precision and high-frequency unattended site calibration and detection of satellites, automatic direction adjustment must be implemented in mirror arrays.
Ruijin Li, Liming Zhang, Xianhua Wang, Weiwei Xu, Xin Li, Jiawei Li, Chunhui Hu   +6 more
doaj   +1 more source

Calibration of fringe projection profilometry: A comparative review

, 2021
Fringe projection profilometry is widely used for three-dimensional (3D) measurements. System calibration is crucial to fringe projection systems, since it determines how the phase is converted into 3D geometry.
Shijie Feng, Chao Zuo, Liang Zhang, Tianyang Tao, Yan Hu, Wei Yin, Jiaming Qian, Qian Chen   +7 more
semanticscholar   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Simulation Research on Very-Low-Level γ Ray Radiation Field Scattering Radiation

Journal of Isotopes
In order to build a very-low-level γ ray radiation field and its magnitude transfer system，the scattering contribution caused by different mechanical device structure is researched based on the experimental conditions of the Jinping underground ...
Xuan GENG, Zhongbin TENG, Zhongbin HANG, Qiao LI, Minghan JIA, Kaixuan HU, Mingzhe SONG, Yuntao LIU   +7 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source