Results 31 to 40 of about 1,541,689 (245)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Internal Model of Commercial Bank as an Instrument for Measuring Credit Risk of the Borrower in Relation to Financial Performance (Credit Scoring and Bankruptcy Models) [PDF]
Journal of Competitiveness, 2011 Commercial banks generally use different methods and procedures for managing credit risk. The internal rating method in which the client has an important position in the process of granting credit provides a comprehensive assessment of client ...
Belás Jaroslav, Cipovová Eva
doaj
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Measurement of the direct damping derivative in roll of the two calibration missile models [PDF]
FME Transactions, 2013 Measurement of the direct damping derivative in roll in the T-38 wind tunnel is described in this paper. The T-38 wind tunnel data for the Basic Finner Model and Modified Basic Finner model are shown.
Samardžić Marija +4 more
doaj
Improving Calibration of Chemical Gas Sensors for Fire Detection Using Small Scale Setups
Proceedings, 2017 Chemical sensing may be better suited than conventional smoke-based detectors for the detection of certain type of fires, in particular in fires where smoke appears after gas emissions.
Ana Solórzano +2 more
doaj +1 more source
Representational ethical model calibration
npj Digital Medicine, 2022 Equity is widely held to be fundamental to the ethics of healthcare. In the context of clinical decision-making, it rests on the comparative fidelity of the intelligence – evidence-based or intuitive – guiding the management of each individual patient ...
Robert Carruthers +8 more
doaj +1 more source
Explore parameter sensitivities and model calibration in a locally coupled environment [PDF]
, 2004 A locally coupled Single Column Model (SCM) was used for sensitivity analysis and model calibration. The sensitivity analysis was used to identify 32 land-surface parameters which appeared to be more or less sensitive in the locally coupled environment ...
Bastidas, LA +3 more
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Blind PV temperature model calibration
EPJ Photovoltaics, 2023 The determination of module temperature in a photovoltaic (PV) system is a crucial factor in PV modelling and the assessment of system health status. However, the scarcity of on-site temperature measurements poses a challenge, and existing PV temperature
Kladas Anastasios +2 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source