Results 21 to 30 of about 5,948 (178)

Treatment With Ruxolitinib and TAK-779 Enhances GII.17 Human Norovirus Replication and Enables Serial Passaging in Human Intestinal Enteroids. [PDF]

Genes Cells
We aimed to establish a simple method for GII.17 human norovirus (HuNoV) replication and serial passaging using wild‐type J2 human intestinal enteroids (HIEs). Treatment with ruxolitinib and TAK‐779, which target interferon and chemokine signaling, respectively, enhances viral replication and enables serial passaging of GII.17. ABSTRACT Human norovirus
Hiraishi E, Hayashi T, Fujii Y, Kimura H, Murakami K.   +4 more
europepmc   +2 more sources

Long-term dynamics of Norovirus transmission in Japan, 2005–2019 [PDF]

PeerJ, 2021
Norovirus continues to evolve, adjusting its pathogenesis and transmissibility. In the present study, we systematically collected datasets on Norovirus outbreaks in Japan from 2005 to 2019 and analyzed time-dependent changes in the asymptomatic ratio ...
Megumi Misumi, Hiroshi Nishiura
doaj   +2 more sources

A Novel Class of Norovirus Inhibitors Targeting the Viral Protease with Potent Antiviral Activity In Vitro and In Vivo

Viruses, 2021
Human noroviruses (HuNoVs) are the most common cause of viral gastroenteritis resulting annually in ~219,000 deaths and a societal cost of ~USD 60 billion, and no antivirals or vaccines are available.
Jana Van Dycke, Wenhao Dai, Zoe Stylianidou, Jian Li, Arno Cuvry, Emma Roux, Bingqian Li, Jasper Rymenants, Lindsey Bervoets, Peter de Witte, Hong Liu, Johan Neyts, Joana Rocha-Pereira   +12 more
doaj   +1 more source

Additional file 1 of Microsatellite diversity and complexity in the viral genomes of the family Caliciviridae

, 2023
Additional file 1.
Md Gulam Jilani (12560945), Mehboob Hoque (457319), Safdar Ali (12560948)   +2 more
core   +1 more source

The Complexity of Swine Caliciviruses. A Mini Review on Genomic Diversity, Infection Diagnostics, World Prevalence and Pathogenicity

Pathogens, 2022
Caliciviruses are single stranded RNA viruses, non-enveloped structurally, that are implicated in the non-bacterial gastroenteritis in various mammal species.
Irit Davidson, Efthymia Stamelou, Ioannis A. Giantsis, Konstantinos V. Papageorgiou, Evanthia Petridou, Spyridon K. Kritas   +5 more
doaj   +1 more source

Caliciviridae

Intervirology, 1980
The caliciviruses, as a proposed family Caliciviridae, have a distinct virion morphology with cup-shaped depressions on a spherical capsid surface. The viruses have single-stranded RNA, which has a molecular weight about 2.6 x 10(6) and is infectious. The RNA is covalently linked to a small protein. A single major polypeptide is found in the capsid.
F L, Schaffer, H L, Bachrach, F, Brown, J H, Gillespie, J N, Burroughs, S H, Madin, C R, Madeley, R C, Povey, F, Scott, A W, Smith, M J, Studdert   +10 more
openaire   +2 more sources

Discovery of a Novel Class of Norovirus Inhibitors with High Barrier of Resistance

Pharmaceuticals, 2021
Human noroviruses (HuNoVs) are the most common cause of viral gastroenteritis resulting in ~219,000 deaths annually and a societal cost of ~USD60 billion. There are no antivirals or vaccines available to treat and/or prevent HuNoV.
Jana Van Dycke, Michela Puxeddu, Giuseppe La Regina, Eloise Mastrangelo, Delia Tarantino, Jasper Rymenants, Jessica Sebastiani, Marianna Nalli, Jelle Matthijnssens, Johan Neyts, Romano Silvestri, Joana Rocha-Pereira   +11 more
doaj   +1 more source

Family Caliciviridae

, 2017
Susan Payne
openaire   +2 more sources

Phylogenetic Diversity and Geographic Distribution of Atlantic Salmon Calicivirus in Major Salmon Farming Regions. [PDF]

J Fish Dis
ABSTRACT Salovirus is a genus within the family Caliciviridae, which contains a single member species, Salovirus nordlandense, also known as Atlantic salmon calicivirus (ASCV). While previous work has shown that ASCV can replicate in fish cell lines and establish systemic infection in vivo, its exact role in disease remains unclear and very little is ...
Costa VA, Mikalsen AB, Samsing F.
europepmc   +2 more sources

Increase of GII.17 Norovirus Infections During the 2024-2025 Season in Multiple Cities, China. [PDF]

J Med Virol
ABSTRACT A significant numerical increase of genotype GII.17 norovirus‐associated sporadic infections was observed in multiple cities in China during the 2024–2025 season. We collected fecal samples from hospitalized children with acute gastroenteritis from 29 sentinel hospitals nationwide to screen for norovirus.
Zheng W, Mu X, Wang S, Qiu T, Wang X.
europepmc   +2 more sources