Results 141 to 150 of about 5,467,731 (352)

California's Most Vulnerable Parents: When Maltreated Children Have Children [PDF]

open access: yes, 2013
This report takes an in-depth look at the intersection between teen births, child maltreatment, and involvement with the child protection system. Putnam-Hornstein, along with other researchers at USC and the University of California, Berkeley, linked and
Barbara Needell   +3 more
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

New Deal Art: California [PDF]

open access: yes, 1976
Traditionally, the years of the New Deal projects have been treated as a part of the Depression experience with an emphasis on their economic and social dimensions.
de Saisset Art Gallery and Museum   +2 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

Salud mental y tecnologías móviles en comunidades indígenas transnacionales

open access: yesFrontera Norte, 2016
El artículo explora el potencial de las tecnologías móviles para la atención de la salud mental en comunidades indígenas transnacionales. e l c aso de estudio es s a n m i guel, o a xaca, cuya pobla - ción radica en diferentes localidades de m é ...
Maximino Matus Ruiz   +3 more
doaj  

Lost Youth: A County-by-County Analysis of 2011 California Homicide Victims Ages 10 to 24 [PDF]

open access: yes, 2013
Homicide is the second leading cause of death for California youth and young adults ages 10 to 24 years old. In 2010, the most recent year for which complete data is available from the federal Centers for Disease Control and Prevention (CDC), homicides ...
Jennifer Lynn-Whaley   +2 more
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

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