Results 231 to 240 of about 293,270 (299)

Dual-receptor targeting of type I dendritic cells with DNA-scaffolded nanoparticles enhances STING-licensed antitumor immunity. [PDF]

Sci Adv
Jana D, Herdes E, Moustouka J, Mash KM, Chen J, Ebeid K, Sallam M, Abbasi A, Desai T.   +8 more
europepmc   +1 more source

Disengaging the Engine: Histone Deacetylases 1 and 2‐Mediated Acetylation of Hexokinase‐2 Regulates Energy Metabolism in Microglia Following Intracerebral Hemorrhage

Advanced Science, EarlyView.
This study demonstrates that HDAC1/2 knockout in microglia alleviates neurological deficits, preserves white matter, and accelerates hematoma clearance after ICH. HDAC1/2 inhibition reduces HK2 acetylation, shifts metabolism from glycolysis to fatty acid oxidation, reduces inflammation, and enhances phagocytosis.
Zhiwen Jiang, Heng Yang, Xinjie Gao, Zengyu Zhang, Ruiyuan Weng, Yuchao Fei, Jiabin Su, Hanqiang Jiang, Wei Ni, Yuxiang Gu   +9 more
wiley   +1 more source

Engineering noncovalent π-stacked organic framework for intrinsic near-infrared photoactivated drug delivery. [PDF]

Sci Adv
Fu R, Meng D, Han X, Liu L, Chen C, Zheng R, Zhao Y, Zhang X, Lin X, Hasani M, Song Y, Liang T, Wen D, Li H, Yavuz I, Feng H, Gu Z, Li Z, Li S, Liu F, Yang Y.   +20 more
europepmc   +1 more source

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

Advanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro   +28 more
wiley   +1 more source

Discovery of Coronavirus Main Protease Inhibitors with Enhanced Brain Exposure and Potent Oral Efficacy in SARS-CoV-2 and MERS Infection Models. [PDF]

J Med Chem
Lizzadro L, Li J, Taha TY, Degotte G, Detomasi TC, Zapatero-Belinchon FJ, Hantz ER, Huang S, Matsui Y, Henderson WR, McCann JT, Montano M, Rosecrans J, Torres Pomares DF, McGovern BL, Diaz-Tapia R, Benjamin J, Gordon ME, Suazo ID, Settineri NS, Diallo A, Krogan NJ, Shoichet BK, Verba KA, Albrecht R, García-Sastre A, White KM, Ott M, Craik CS, Renslo AR.   +29 more
europepmc   +1 more source

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

Advanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu   +16 more
wiley   +1 more source

Severe pincer morphology is associated with incident hip osteoarthritis: prospective individual participant data from 18 935 hips from the World COACH consortium. [PDF]

Br J Sports Med
Riedstra N, Boel F, van Buuren MM, Ahedi H, Arbabi V, Arden NK, Baart SJ, Bierma-Zeinstra SMA, Cicutini F, Cootes T, Crossley KM, Felson DT, Gielis WP, Heerey JJ, Jones G, Kluzek S, Lane NE, Lindner C, Lynch JA, van Meurs J, Mosler AB, Nelson AE, Nevitt MC, Oei EHG, Runhaar J, Tang J, Weinans H, Agricola R.   +27 more
europepmc   +1 more source

Indole‐3‐Propionic Acid Improves Alveolar Development Impairment via Targeting VAMP8‐mediated SNAREs Complex Formation in Bronchopulmonary Dysplasia

Advanced Science, EarlyView.
This study aims to evaluate the impact of the tryptophan‐derived metabolite indole‐3‐propionic acid (IPA) on lung development and autophagic flux. IPA alleviates hyperoxia‐induced alveolar arrest by promoting autophagosome‐lysosome fusion via inhibition of VAMP8 phosphorylation, which is suggestive of a promising therapeutic target of BPD.
Beibei Wang, Xu Chen, Haowei Xu, Zhiqi Zeng, Keyu Lu, Yu Mao, Qianru Lv, Hui Shi, Song Liu, Xian Shen, Chunyu Yin, Yang Yang, Yan Guo, Xingyun Wang, Rui Cheng   +14 more
wiley   +1 more source

<i>N</i>-Acetylcysteine and pro-adrenomedullin dual-crosslinked gelatin-chitosan hydrogels with enhanced mechanical and mineralization performance. [PDF]

RSC Adv
Zertuche-Arias T, Alatorre-Meda M, Rivero IA, Juárez P, Castro-Ceseña AB.   +4 more
europepmc   +1 more source

Mo-Catalyzed Asymmetric Allylic Alkylation Enabling the Construction of Highly Enantioenriched 1,4-Dicarbonyl Scaffolds. [PDF]

J Am Chem Soc
Cerione CS, Moghadam FA, Stoltz BM.
europepmc   +1 more source