Results 41 to 50 of about 40,382 (258)

Utilization of Black Cotton Soil Stabilized with Brick Dust-Lime for Pavement Road Construction: An Experimental and Numerical Approach

The Baltic Journal of Road and Bridge Engineering, 2023
Black cotton soil is highly susceptible to volume change due to moisture fluctuations. This leads to the deformation of structures built on such soil. Therefore, the aim of this study is to improve the soil-bearing capacity and deformation analysis of ...
Damtew Melese, Belete Aymelo, Tewodros Weldesenbet, Alemineh Sorsa   +3 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

California Bearing Ratio of Some Iraqi Dune Soils

Tikrit Journal of Engineering Sciences, 2015
   This paper contains the results of CBR tests that performed on compacted samples of real dune sand (cohesionless sand grains) and pseudo dune sand which is a mixture of sand sized  aggregate of  clay and silt.
Yousif Al-Shakarchi, Bushra S. Zbar Al-Busoda, Abbas J. Al Taie   +2 more
doaj  

Terrace Soil Suitability for Highway Construction: Case Study in Lesser Himalaya (CPEC Project E-35), North Pakistan

International Journal of Economic and Environment Geology, 2021
In this study, terrace soil investigation was carried out in project E-35 (phase-I) China-Pak Economic Corridor, Lesser Himalayas, North Pakistan. The methodology in current research is based on tests that include sieve analysis, plastic index, proctor ...
Salman Ahmed Khattak , Anwar Qadir , Hamza Daud , Kamran Shehzad , Muhammad Yasir , Muhammad Abubakar   +5 more
doaj   +1 more source

Predicting California Bearing Ratio (CBR) Value of a Selected Subgrade Material

, 2022
The subgrade bearing capacity is an important parameter in flexible pavement design, and it is largely influenced by the variation of subgrade moisture. California Bearing Ratio (CBR) is the most popular method of assessing the subgrade bearing capacity. It compares the load required to make a particular penetration on a given subgrade with the load to
Kasun Wimalasena, Chaminda Gallage
openaire   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

An assessment of how penetration curve adjustment affects the California bearing ratio (CBR)

Studia Geotechnica et Mechanica, 2021
With the rapidly developing road transport, there is a demand for new roads to be constructed and for the existing ones to be repaired or extended. The base of any road is its foundation, usually made of crushed or uncrushed aggregate.
Bednarek Łukasz
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source