Results 51 to 60 of about 293,289 (282)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

An experimental study of the California bearing ratio of basalt fiber reinforced loess

open access: yesShuiwen dizhi gongcheng dizhi, 2021
In order to study the factors affecting the CBR value of the fiber-reinforced loess and the mechanism of the fiber-reinforced soil, chopped basalt fiber was used as the reinforcement material, and the CBR test was performed by changing the moisture ...
Peida LI   +3 more
doaj   +1 more source

Pengaruh Kadar Lempung dan Kadar Air pada Sisi Basah terhadap Nilai CBR pada Tanah Lempung Kepasiran (Sandy Clay) [PDF]

open access: yes, 2014
CBR (California Bearing Ratio) is one method for determining the bearing capacity of the subgrade . In highway planning , subgrade bearing capacity will affect the pavement thickness, the higher bearing capacity of subgrade makes the pavement thickness ...
Fatnanta, F. (Ferry)   +2 more
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Utilization of Black Cotton Soil Stabilized with Brick Dust-Lime for Pavement Road Construction: An Experimental and Numerical Approach

open access: yesThe Baltic Journal of Road and Bridge Engineering, 2023
Black cotton soil is highly susceptible to volume change due to moisture fluctuations. This leads to the deformation of structures built on such soil. Therefore, the aim of this study is to improve the soil-bearing capacity and deformation analysis of ...
Damtew Melese   +3 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

California Bearing Ratio of Some Iraqi Dune Soils

open access: yesTikrit Journal of Engineering Sciences, 2015
   This paper contains the results of CBR tests that performed on compacted samples of real dune sand (cohesionless sand grains) and pseudo dune sand which is a mixture of sand sized  aggregate of  clay and silt.
Yousif Al-Shakarchi   +2 more
doaj  

Illustrated key to Penaeoid shrimps of commerce in the Americas [PDF]

open access: yes, 1988
The commercially important species of penaeoid shrimps comprise 4 families, 12 genera, and 37 species in the Americas, This key is supported by 49 figures including lateral views of whole shrimps in 10 of the 12 genera and detailed figures of male ...
Farfante, Isabel Perez
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

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