Results 61 to 70 of about 293,289 (282)

An assessment of how penetration curve adjustment affects the California bearing ratio (CBR)

Studia Geotechnica et Mechanica, 2021
With the rapidly developing road transport, there is a demand for new roads to be constructed and for the existing ones to be repaired or extended. The base of any road is its foundation, usually made of crushed or uncrushed aggregate.
Bednarek Łukasz
doaj   +1 more source

Terrace Soil Suitability for Highway Construction: Case Study in Lesser Himalaya (CPEC Project E-35), North Pakistan

International Journal of Economic and Environment Geology, 2021
In this study, terrace soil investigation was carried out in project E-35 (phase-I) China-Pak Economic Corridor, Lesser Himalayas, North Pakistan. The methodology in current research is based on tests that include sieve analysis, plastic index, proctor ...
Salman Ahmed Khattak , Anwar Qadir , Hamza Daud , Kamran Shehzad , Muhammad Yasir , Muhammad Abubakar   +5 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

EFFECT OF WASTE MATERIALS ON CALIFORNIA BEARING RATIO FOR GRANULAR BASE

Journal of Engineering and Sustainable Development, 2021
It is known that paving is a system with multiple layers and the strength of each layer is reflected on the entire pavement. Two kinds of materials are used as the base layer, and the materials are divided into ordinary traditional granular materials and recycled materials such as foundry sand. This paper presents the results of laboratory tests in the
Jleel H. Rasheed, Zainab A. Alkaissi, Hanan A. Hassan   +2 more
openaire   +1 more source

Co-delivery of human cancer-testis antigens with adjuvant in protein nanoparticles induces higher cell-mediated immune responses. [PDF]

, 2018
Nanoparticles have attracted considerable interest as cancer vaccine delivery vehicles for inducing sufficient CD8+ T cell-mediated immune responses to overcome the low immunogenicity of the tumor microenvironment.
Kim, Tae Il, Molino, Nicholas M, Neek, Medea, Nelson, Edward L, Tucker, Jo Anne, Wang, Szu-Wen   +5 more
core   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Pengaruh Penambahan Kapur dan Lama Waktu Pemeraman pada Tanah Pasir Berlempung terhadap Kekuatan Tanah (California Bearing Ratio) [PDF]

, 2017
Pada penelitian ini akan dicoba masalah yang dititik beratkan pada pengaruh penambahan kapur pada tanah lempung berpasir serta lama waktu pemeraman sebagai bahan campuran guna meningkatkan stabilitas tanah pada lapisan tanah yang kurang baik.
SUGITO, S. (Sugito)
core  

Deep lithospheric dynamics beneath the Sierra Nevada during the Mesozoic and Cenozoic as inferred from xenolith petrology [PDF]

, 2001
Peridotite xenoliths erupted in late Miocene basalts (~8 Ma) in the central Sierra Nevada sample a lithosphere that is vertically stratified in terms of age and thermal history.
Brimhall, George H., Jr., Lee, Cin-Ty, Rudnick, Roberta L.   +2 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source