Results 151 to 160 of about 5,948,176 (309)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Using causal effect estimation to evaluate occupational stress factors during a weekend on-call shift among general practitioners in training. [PDF]

BMC Prim Care
Deberdt G, Rabaey P, Van Damme S, Quenon LA, Decat P, Demeester T.   +5 more
europepmc   +1 more source

Call for Papers [PDF]

, 2015
Nolan, Stuart, Taylor, Nik
core   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Educational Interventions to Prepare Undergraduate Students for Out-of-Hours Practice as a Newly Qualified Doctor in the United Kingdom: A Scoping Review. [PDF]

Clin Teach
Gordon A, Parkinson M, Watts R, El-Badawi K, Dawson E, Chiktara R, Burns L, Brennan N.   +7 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Geriatric Helpline Services to Improve Health and Care Pathways in Older Adults: A Cost-Effectiveness Analysis. [PDF]

Health Sci Rep
Mourgues C, Bongue B, Dupré C, Goethals L, Celarier T, Blanquet M.   +5 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Artificial Intelligence for Hospital Scheduling: A Simple, Reproducible, and Effective Model. [PDF]

Cureus
Biot C, Tabbuso T, Marechal Y.
europepmc   +1 more source

California's recent performance [PDF]

California ; Federal Reserve District ...
Carolyn Sherwood-Call, Ronald H. Schmidt
core