Results 61 to 70 of about 270,797 (333)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The Potential of Fasting and Caloric Restriction to Mitigate Radiation Damage—A Systematic Review

Frontiers in Nutrition, 2020
Detrimental health effects from ionizing radiation to living organisms is one of the key concerns identified and addressed by Radiation Protection institutions, nationally and internationally on Earth and for human spaceflight.
Simon Valayer, Simon Valayer, David Kim, David Kim, Anna Fogtman, Ulrich Straube, Andrew Winnard, Nick Caplan, David A. Green, David A. Green, David A. Green, Flora H. P. van Leeuwen, Flora H. P. van Leeuwen, Tobias Weber, Tobias Weber   +14 more
doaj   +1 more source

Clinical Nutritional Study of Minimum Protein and Caloric Requirements for Man. Annual Report, Sep. 1965 - Sep. 1966 [PDF]

, 1966
Minimum protein and caloric requirements for prolonged manned spaceflight and space ...
Calloway, D. H., Margen, S.
core   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Early postnatal caloric restriction protects adult male intrauterine growth-restricted offspring from obesity. [PDF]

, 2012
Postnatal ad libitum caloric intake superimposed on intrauterine growth restriction (IUGR) is associated with adult-onset obesity, insulin resistance, and type 2 diabetes mellitus (T2DM).
Dai, Yun, Devaskar, Sherin U, Garg, Meena, Shin, Bo-Chul, Stout, David, Thamotharan, Manikkavasagar, Thamotharan, Shanthie   +6 more
core   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Consumption of ultra-processed foods and socioeconomic position: a cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health

Cadernos de Saúde Pública, 2018
The objective of the study was to estimate the contribution of ultra-processed foods to total caloric intake and investigate whether it differs according to socioeconomic position.
Bárbara dos Santos Simões, Letícia de Oliveira Cardoso, Isabela Judith Martins Benseñor, Maria Inês Schmidt, Bruce Bartholow Duncan, Vivian Cristine Luft, Maria del Carmen Bisi Molina, Sandhi Maria Barreto, Renata Bertazzi Levy, Luana Giatti   +9 more
doaj   +1 more source

On the efficiency of caloric materials in direct comparison with exergetic grades of compressors

JPhys Energy, 2023
Efficiency improvements in heat pump can drastically reduce global energy demand. Caloric heat pumps are currently being investigated as a potentially more efficient alternative to vapor compression systems.
Jan Schipper, David Bach, Stefan Mönch, Christian Molin, Sylvia Gebhardt, Jürgen Wöllenstein, Olaf Schäfer-Welsen, Christian Vogel, Robin Langebach, Kilian Bartholomé   +9 more
doaj   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

Relativistic Thomas-Fermi description of Sm isotopes at finite temperature

, 2001
The caloric curve (excitation energy per particle as a function of temperature) for finite nuclei is calculated within the non-linear Walecka model for different proton fractions and different parameterizations.
Baron, Baron, Berghammer, Berghammer, Bodmer, Bodmer, Boguta, Bugaev, Bugaev, C. Providência, Centelles, Chbihi, D.P. Menezes, De, De, Frankland, Gambir, Goodman, Hagel, Hauger, Kahana, Krein, L. Brito, Lalazissis, Larionov, Lattimer, Li, Lindsay, Menezes, Menezes, Menezes, Müller, Pethick, Pochodzalla, Reinhard, Reinhardt, Rolfs, Samaddar, Schen, Serot, Sil, Sommerfeld, Sumiyoshi, Sumiyoshi, von Eiff, Vretenar, Yennello   +46 more
core   +2 more sources