Results 71 to 80 of about 160,862 (306)
Study of caloric value in Cyclobanopsis glauce population
Caloric values of leaf, branch and stem are different with various diameter-classes of Cyclobanopsis glauca population. To the same trophic organ in the same diameter-class, the seedling's caloric value is greater than that of coppice, and the difference
NI Sui, CHEN Qi-chang
doaj +1 more source
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Background Meniere’s disease (MD) is marked by fluctuating hearing loss, episodic vertigo, aural fullness, and tinnitus. Vestibulo-ocular reflex (VOR) assessment through video head impulse test (vHIT), caloric testing, and ocular vestibular evoked ...
Mohamed Ibrahim Shabana +4 more
doaj +1 more source
Effect of Caloric Restriction on Hepatic Sinusoidal System and Stellate Cells in Mice
Aging associated changes in liver include reduced hepatic blood flow, increased number of stellate cells, and collagen deposits in perisinusoidal space. We tested the possibility of mitigating these changes with caloric restriction.
Jian Chen, Kara King, Jian X. Zhang
doaj +1 more source
Journal of Chronic Diseases 40 (1987) 911-911. doi:10.1016/0021-9681(87)90194-9 ; Received by publisher: 0000-01-01 ; Harvest Date: 2016-01-04 12:20:01 ; DOI:10.1016/0021-9681(87)90194-9 ; Page Range: 911 ...
Department of Psychiatry University of Florida College of Medicine Gainesville FL 32610 U.S.A. ( host institution ) +1 more
openaire +3 more sources
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source

