Results 71 to 80 of about 260,179 (301)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Inhibition of food intake in obese subjects by peptide YY3-36 [PDF]

, 2003
Background: The gut hormone fragment peptide YY3-36 (PYY) reduces appetite and food intake when infused into subjects of normal weight. In common with the adipocyte hormone leptin, PYY reduces food intake by modulating appetite circuits in the ...
Batterham, RL, Bloom, SR, Cohen, MA, Ellis, SM, Frost, GS, Ghatei, MA, Le Roux, CW, Withers, DJ   +7 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

A threshold caloric test- results in normal subjects [PDF]

Threshold caloric test on normal subjects - responses to hot and cold caloric ...
Mc Leod, M. E., Meek, J. C.
core   +1 more source

Liquid-gas phase transition in finite nuclei

, 1997
In a finite temperature Thomas-Fermi framework, we calculate density distributions of hot nuclei enclosed in a freeze-out volume of few times the normal nuclear volume and then construct the caloric curve, with and without inclusion of radial collective ...
Bandyopadhyay, Bondorf, De, De, Fisher, Gross, Hauger, J.N. De, Levit, Natowitz, Pal, Pochodzalla, S. Shlomo, S.K. Samaddar   +13 more
core   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Results of video head impulse test, caloric test, and ocular vestibular evoked myogenic potential findings in Meniere’s disease

The Egyptian Journal of Otolaryngology
Background Meniere’s disease (MD) is marked by fluctuating hearing loss, episodic vertigo, aural fullness, and tinnitus. Vestibulo-ocular reflex (VOR) assessment through video head impulse test (vHIT), caloric testing, and ocular vestibular evoked ...
Mohamed Ibrahim Shabana, Abeir Osman Dabbous, Zahraa Mohamed Yousry Elbohy, Zainab Tarek Sayed Abd-Elaleim, Mariam Magdy Medhat   +4 more
doaj   +1 more source

Effect of Caloric Restriction on Hepatic Sinusoidal System and Stellate Cells in Mice

Journal of Aging Research, 2014
Aging associated changes in liver include reduced hepatic blood flow, increased number of stellate cells, and collagen deposits in perisinusoidal space. We tested the possibility of mitigating these changes with caloric restriction.
Jian Chen, Kara King, Jian X. Zhang
doaj   +1 more source

Consumption of ultra-processed foods and socioeconomic position: a cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health

Cadernos de Saúde Pública, 2018
The objective of the study was to estimate the contribution of ultra-processed foods to total caloric intake and investigate whether it differs according to socioeconomic position.
Bárbara dos Santos Simões, Letícia de Oliveira Cardoso, Isabela Judith Martins Benseñor, Maria Inês Schmidt, Bruce Bartholow Duncan, Vivian Cristine Luft, Maria del Carmen Bisi Molina, Sandhi Maria Barreto, Renata Bertazzi Levy, Luana Giatti   +9 more
doaj   +1 more source