Results 71 to 80 of about 160,862 (306)

Study of caloric value in Cyclobanopsis glauce population

open access: yes浙江大学学报. 农业与生命科学版, 2001
Caloric values of leaf, branch and stem are different with various diameter-classes of Cyclobanopsis glauca population. To the same trophic organ in the same diameter-class, the seedling's caloric value is greater than that of coppice, and the difference
NI Sui, CHEN Qi-chang
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Results of video head impulse test, caloric test, and ocular vestibular evoked myogenic potential findings in Meniere’s disease

open access: yesThe Egyptian Journal of Otolaryngology
Background Meniere’s disease (MD) is marked by fluctuating hearing loss, episodic vertigo, aural fullness, and tinnitus. Vestibulo-ocular reflex (VOR) assessment through video head impulse test (vHIT), caloric testing, and ocular vestibular evoked ...
Mohamed Ibrahim Shabana   +4 more
doaj   +1 more source

Effect of Caloric Restriction on Hepatic Sinusoidal System and Stellate Cells in Mice

open access: yesJournal of Aging Research, 2014
Aging associated changes in liver include reduced hepatic blood flow, increased number of stellate cells, and collagen deposits in perisinusoidal space. We tested the possibility of mitigating these changes with caloric restriction.
Jian Chen, Kara King, Jian X. Zhang
doaj   +1 more source

Obesity and caloric intake

open access: yesJournal of Chronic Diseases, 1987
Journal of Chronic Diseases 40 (1987) 911-911. doi:10.1016/0021-9681(87)90194-9 ; Received by publisher: 0000-01-01 ; Harvest Date: 2016-01-04 12:20:01 ; DOI:10.1016/0021-9681(87)90194-9 ; Page Range: 911 ...
Department of Psychiatry University of Florida College of Medicine Gainesville FL 32610 U.S.A. ( host institution )   +1 more
openaire   +3 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Home - About - Disclaimer - Privacy