Results 61 to 70 of about 260,179 (301)

Soluble Fermentable Dietary Fibre (Pectin) Decreases Caloric Intake, Adiposity and Lipidaemia in High-Fat Diet-Induced Obese Rats [PDF]

, 2015
Funding: This work was funded by the Scottish Government Rural and Environment Science and Analytical Services Division. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer ...
Adam, Clare L, Ross, Alexander W, Thomson, Lynn M, Williams, Patricia A   +3 more
core   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Relativistic Thomas-Fermi description of Sm isotopes at finite temperature

, 2001
The caloric curve (excitation energy per particle as a function of temperature) for finite nuclei is calculated within the non-linear Walecka model for different proton fractions and different parameterizations.
Baron, Baron, Berghammer, Berghammer, Bodmer, Bodmer, Boguta, Bugaev, Bugaev, C. Providência, Centelles, Chbihi, D.P. Menezes, De, De, Frankland, Gambir, Goodman, Hagel, Hauger, Kahana, Krein, L. Brito, Lalazissis, Larionov, Lattimer, Li, Lindsay, Menezes, Menezes, Menezes, Müller, Pethick, Pochodzalla, Reinhard, Reinhardt, Rolfs, Samaddar, Schen, Serot, Sil, Sommerfeld, Sumiyoshi, Sumiyoshi, von Eiff, Vretenar, Yennello   +46 more
core   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

The effects of graded levels of calorie restriction : III. Impact of short term calorie and protein restriction on mean daily body temperature and torpor use in the C57BL/6 mouse [PDF]

, 2015
GRANT SUPPORT This work was supported by BBSRC BB009953/1 awarded to JRS and SEM. PK and CD were funded by the Erasmus exchange programme. JRS, SEM, DD, CG, LC, JJDH, YW, DELP, DL and AD are members of the BBSRC China Partnership Award, BB/J020028/1.Peer
Chen, Luonan, Delville, Camille, Derous, Davina, Douglas, Alex, Green, Cara L., Han, Jing-Dong J., Konstantopedos, Penelope, Lusseau, David, Mitchell, Sharon E., Promislow, Daniel E.L., Speakman, John R., Wang, Yingchun   +11 more
core   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Study of caloric value in Cyclobanopsis glauce population

浙江大学学报. 农业与生命科学版, 2001
Caloric values of leaf, branch and stem are different with various diameter-classes of Cyclobanopsis glauca population. To the same trophic organ in the same diameter-class, the seedling's caloric value is greater than that of coppice, and the difference
NI Sui, CHEN Qi-chang
doaj   +1 more source

The Potential of Fasting and Caloric Restriction to Mitigate Radiation Damage—A Systematic Review

Frontiers in Nutrition, 2020
Detrimental health effects from ionizing radiation to living organisms is one of the key concerns identified and addressed by Radiation Protection institutions, nationally and internationally on Earth and for human spaceflight.
Simon Valayer, Simon Valayer, David Kim, David Kim, Anna Fogtman, Ulrich Straube, Andrew Winnard, Nick Caplan, David A. Green, David A. Green, David A. Green, Flora H. P. van Leeuwen, Flora H. P. van Leeuwen, Tobias Weber, Tobias Weber   +14 more
doaj   +1 more source