Results 141 to 150 of about 384,773 (212)

z‐VAD‐FMK triggers macrophage necroptosis during mycobacterial infection via a non‐canonical off‐target mechanism

mLife, EarlyView.
Abstract Macrophages are the predominant cell type infected by Mycobacterium tuberculosis (Mtb) in tuberculosis (TB). Death of Mtb‐infected macrophages promotes tissue pathology and releases Mtb to infect other cells, suggesting that inhibiting the death of Mtb‐infected macrophages could be an adjunctive treatment of TB.
Rong Hu, Pei Li, Jie Han, Jiamin Huang, Guoyi Huang, Xiuju Jiang, Daniel Pfau, Guobao Li, Yi‐Nan Gong, Carl F. Nathan, Li Zhang   +10 more
wiley   +1 more source

Peptide‐based antibacterial nanoplatforms: Design principles, stimuli‐regulated behaviors, and applications

Responsive Materials, EarlyView.
Peptide‐based antibacterial nanoplatforms, encompassing self‐assembled peptides and peptide‐engineered inorganic, polymeric, and lipid nanocarriers, are systematically reviewed. The article highlights design principles and stimuli‐responsive regulation for improving peptide stability, delivery efficiency, and antibacterial performance.
Peng Tan, Chenlong Zhou, Shuaikang Yang, Zhenduo Chen, Guanghui Zhao, Qi Tang, Haoyu Yan, Feng Li, Xi Ma   +8 more
wiley   +1 more source

A Retinomorphic Graphene Transistor Implementing Direction‐ and Velocity‐Selective Computation for In‐Sensor Image Stabilization

Small, EarlyView.
A multi‐gated ion‐gel graphene transistor architecture emulates spatiotemporal dendritic filtering inspired by biological direction‐selective retinal circuits. Leveraging distributed resistance‐capacitive ionic relaxation delays under combined excitation‐inhibition pulse routines, the solid‐state device exhibits programmable direction‐selective index ...
Jun Ha Park, HoYeon Kim, Jinkyung Kim, Hyun Jae Jang, Jae Wook Kim, Jongkil Park, Seongsik Park, Inho Kim, Suyoun Lee, Gyu Weon Hwang, Byeong‐Kwon Ju, Kyeong‐Seok Lee   +11 more
wiley   +1 more source

Oppositely Charged Homopolypeptides Form Ordered Helix Assemblies With Hierarchical Structure

Small, EarlyView.
Hexagaonal and square assembly of polyarginine alfa‐helices formed in highly ordered polyarginine/polyaspartic acid complexes. The helices exhibit additional periodic staggering along their helical axis. ABSTRACT Oppositely charged polyelectrolytes are known to form polyelectrolyte complexes.
Ekaterina Buvalaia, Martin Dulle, Benoit David, Karoline Rengel, Michael Ohl, Beate Förster, Margarita Kruteva, Henrike Heise, Ralf Biehl, Holger Gohlke, Stephan Förster   +10 more
wiley   +1 more source

Advances in research on layered double hydroxides for biomedical applications

Smart Molecules, EarlyView.
Layered double hydroxides (LDHs) are pH‐responsive nanomaterials with broad biomedical applications. This review summarizes LDH synthesis methods and compares their advantages. It highlights LDHs' progress in cancer therapy, including chemo‐photothermal, chemo‐immunotherapy, and photodynamic‐immunotherapy combinations and their potential in bone repair.
Xinhui Yang, Zhiping Zhang, Zhao Wang, Hao Zhang, Yen Leng Pak, Yingying Jing, Yurong Guo, Fang Li, Xiao Wang, Quanxiang Han, Lei Yu, Xuejiao Li, Xing Gao, Jibin Song   +13 more
wiley   +1 more source

Alleviation of senescence and epithelial-mesenchymal transition in aging kidney by short-term caloric restriction and caloric restriction mimetics via modulation of AMPK/mTOR signaling. [PDF]

Oncotarget, 2017
Dong D, Cai GY, Ning YC, Wang JC, Lv Y, Hong Q, Cui SY, Fu B, Guo YN, Chen XM.   +9 more
europepmc   +1 more source

Harnessing the nonthermal effects of ultrasound for cancer treatment: From mechanisms to applications

Smart Molecules, EarlyView.
Nonthermal ultrasound transforms acoustic energy into diverse therapeutic bioeffects through cavitation, mechanical stimulation, and physicochemical activation. This review discusses how acoustic parameters, biological mechanisms, and responsive materials interact to influence nonthermal ultrasound‐enabled cancer therapies. Mechanism‐guided engineering
Liu Wang, Huan Tang, Yue Pan, Mingle Li, Weijie Zhao, Kai Liu   +5 more
wiley   +1 more source

Peptide‐directed nanovehicles enabling tumor‐selective ROS amplification and antitumor immunity

VIEW, EarlyView.
Cancer cells are vulnerable to oxidative stress, yet exploit immune tolerance to escape destruction. In contrast, their metabolic profile is markedly altered to support rapid proliferation, accompanied by elevated production of reactive oxygen species (ROS).
Manuela Calin, Galyna Bila, Ileana Manduteanu, Rostyslav Bilyy   +3 more
wiley   +1 more source

Nanomedicine applications in lymphoma: Advancing precision diagnostics, targeted therapeutics, and prospective developments

VIEW, EarlyView.
Lymphoma is a group of blood cancers that can appear in lymph nodes, blood, bone marrow, spleen, liver, or the central nervous system, which makes drug delivery and disease monitoring difficult. This review summarizes how nanomedicine technologies may improve targeted treatment and imaging, while carefully separating approved or guideline‐supported ...
Mohd Ahmar Rauf, Yara Mashal, Afeefa Rao, Nasar Ata, Arun K. Iyer, Farhan Shah   +5 more
wiley   +1 more source

Progress in bone tissue engineering biomaterials: Development, challenges, and prospects

VIEW, EarlyView.
Scheme 1 Application of biomaterials in immunomodulation during bone tissue engineering. Abstract Bone defect repair remains a major clinical challenge in orthopedics. Over 2 million cases caused by trauma, tumors, and other factors occur annually, with large‐scale defects posing a particular bottleneck due to limited self‐healing capacity.
Yuanbin Zhang, Junlei Chai, Quanwei Ding, Luping Liu, Kejie Zhang, Jie Lin, Jianhua Zhang, Youju Huang   +7 more
wiley   +1 more source