Results 41 to 50 of about 6,700,125 (247)

Comparative utility of vestibular function tests in patients with peripheral and central vestibular dysfunction

Journal of Otology
Background: Bithermal caloric irrigation, video head impulse test (vHIT), and rotational testing are commonly used to assess peripheral vestibular function, but the relative clinical utility of each test in differentiating patients with peripheral ...
Cameron B. Fattahi, Christopher Zaro, Janice J. Chung, Richard F. Lewis, Divya A. Chari   +4 more
doaj   +1 more source

Do Caloric Test Results Affect the Prognosis of Sudden Hearing Loss?

, 2017
Aim: The aim of this study is to evaluate the prognostic value of caloric test results in patients with sudden hearing loss.Material -Method: We evaluated 23 patients with sudden hearing loss who were hospitalized.
Süha Beton, Muharrem Gerçeker
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Noninvasive brain oxygen saturation measurement during caloric response in vertigo patients—preliminary report

Frontiers in Neurology
IntroductionAlthough videonystagmography (VNG) is a useful test for evaluating patients with vestibular symptoms, it may cause undesirable side effects.
Magdalena Nowaczewska, Maria Marzec, Łukasz Kluczyński, Łukasz Kluczyński, Katarzyna Sierakowska, Maciej Wróbel   +5 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

High-Frequency Vestibular Function Is Vulnerable to Presbyvestibulopathy

Diagnostics
Introduction: In 2019, mild vestibular function deficiency in elder populations was defined as presbyvestibulopathy (PVP) by the Classification Committee of the Bárány Society.
Seonghoon Bae, Jimin Yun, Seungmin Kwak, Hyuntaek Jung, Hancheol Lee, Juyoung Kim, Chanhee Kim, Yujin Lee, Sunghuhn Kim   +8 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Evaluating children with vestibular migraine through vestibular test battery: A cross-sectional investigation

Frontiers in Neurology, 2022
ObjectiveThe present study aimed to investigate the status of vestibular function in children with vestibular migraine of childhood (VMC) reflected by vestibular function test battery and explore the pathophysiological implication of these instrument ...
Fan Zhang, Jiali Shen, Qi Zhu, Lu Wang, Xiaobao Ma, Baihui He, Yang Yang, Wei Wang, Xiangping Chen, Qing Zhang, Yulian Jin, Maoli Duan, Jianyong Chen, Jun Yang   +13 more
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source