Results 41 to 50 of about 79,365 (259)

Evaluating children with vestibular migraine through vestibular test battery: A cross-sectional investigation

Frontiers in Neurology, 2022
ObjectiveThe present study aimed to investigate the status of vestibular function in children with vestibular migraine of childhood (VMC) reflected by vestibular function test battery and explore the pathophysiological implication of these instrument ...
Fan Zhang, Jiali Shen, Qi Zhu, Lu Wang, Xiaobao Ma, Baihui He, Yang Yang, Wei Wang, Xiangping Chen, Qing Zhang, Yulian Jin, Maoli Duan, Jianyong Chen, Jun Yang   +13 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Relationship between vestibular dysfunction and freezing of gait in Parkinson disease

徐州医科大学学报
Objective To investigate the relationship between vestibular dysfunction and freezing of gait (FOG) in Parkinson disease (PD). Methods A total of 52 PD patients who met the inclusion criteria from the PD Center Database of Nanjing First Hospital, Nanjing
SHI Jialiang, CAI Yanling, HUANG Qing, TIAN Youyong   +3 more
doaj   +1 more source

Saccades Matter: Reduced Need for Caloric Testing of Cochlear Implant Candidates by Joint Analysis of v-HIT Gain and Corrective Saccades

Frontiers in Neurology, 2021
Objectives: Video head impulse test (v-HIT) is a quick, non-invasive and relatively cheap test to evaluate vestibular function compared to the caloric test.
Constanza Fuentealba Bassaletti, Babette F. van Esch, Jeroen J. Briaire, Peter Paul G. van Benthem, Erik F. Hensen, Johan H. M. Frijns, Johan H. M. Frijns   +6 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Comparative utility of vestibular function tests in patients with peripheral and central vestibular dysfunction

Journal of Otology
Background: Bithermal caloric irrigation, video head impulse test (vHIT), and rotational testing are commonly used to assess peripheral vestibular function, but the relative clinical utility of each test in differentiating patients with peripheral ...
Cameron B. Fattahi, Christopher Zaro, Janice J. Chung, Richard F. Lewis, Divya A. Chari   +4 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A simple cold caloric test.

Nippon Jibiinkoka Gakkai Kaiho, 1984
1. 少量注水法による冷水刺激検査を客観的に評価するために,正常者10名に対し,1)20°C 5ml 10秒間注水20秒間刺激(少量注水法)2)20°C 20ml 10秒間注水,3)20°C 50ml 20秒間注水,4)簡易法による冷温交互試験(20ml 10秒間注水)を行った.1),2)は暗所開眼下およびフレンッェル眼鏡下,3),4)は暗所開眼下に観察し,眼振最大緩徐相速度,眼振持続時間を比較した.2. 眼振最大緩徐相速度は注水条件,観察条件により異なり,暗所の20°C 5ml 10秒間注水20秒間刺激が最も反応が強く(34.6度/秒),個体間の変動も小さかった.これに対し簡易法による冷温交互試験ではきわめて反応が弱く,温刺激では冷刺激の約2倍の反応が得られたが,8.4度/秒にすぎなかった ...
MIDORIKAWA, CHIKAKO, TAKAHASHI, MASAHIRO, TSUJITA, NAOMI, HOSHIKAWA, HARUKO   +3 more
openaire   +3 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source