Results 51 to 60 of about 82,719 (294)

Evaluating children with vestibular migraine through vestibular test battery: A cross-sectional investigation

Frontiers in Neurology, 2022
ObjectiveThe present study aimed to investigate the status of vestibular function in children with vestibular migraine of childhood (VMC) reflected by vestibular function test battery and explore the pathophysiological implication of these instrument ...
Fan Zhang, Jiali Shen, Qi Zhu, Lu Wang, Xiaobao Ma, Baihui He, Yang Yang, Wei Wang, Xiangping Chen, Qing Zhang, Yulian Jin, Maoli Duan, Jianyong Chen, Jun Yang   +13 more
doaj   +1 more source

Saccades Matter: Reduced Need for Caloric Testing of Cochlear Implant Candidates by Joint Analysis of v-HIT Gain and Corrective Saccades

Frontiers in Neurology, 2021
Objectives: Video head impulse test (v-HIT) is a quick, non-invasive and relatively cheap test to evaluate vestibular function compared to the caloric test.
Constanza Fuentealba Bassaletti, Babette F. van Esch, Jeroen J. Briaire, Peter Paul G. van Benthem, Erik F. Hensen, Johan H. M. Frijns, Johan H. M. Frijns   +6 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Comparative utility of vestibular function tests in patients with peripheral and central vestibular dysfunction

Journal of Otology
Background: Bithermal caloric irrigation, video head impulse test (vHIT), and rotational testing are commonly used to assess peripheral vestibular function, but the relative clinical utility of each test in differentiating patients with peripheral ...
Cameron B. Fattahi, Christopher Zaro, Janice J. Chung, Richard F. Lewis, Divya A. Chari   +4 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Clinical Implication of Caloric and Video Head Impulse Tests for Patients With Enlarged Vestibular Aqueduct Presenting With Vertigo

Frontiers in Neurology, 2021
Background: By examining the clinical features and results of video head impulse test (vHIT) and caloric tests in patients with enlarged vestibular aqueduct (EVA) presenting with vertigo, we aimed to investigate the function of angular vestibulo-ocular ...
Ming Li, Yangming Leng, Bo Liu
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

A simple cold caloric test.

Nippon Jibiinkoka Gakkai Kaiho, 1984
1. 少量注水法による冷水刺激検査を客観的に評価するために,正常者10名に対し,1)20°C 5ml 10秒間注水20秒間刺激(少量注水法)2)20°C 20ml 10秒間注水,3)20°C 50ml 20秒間注水,4)簡易法による冷温交互試験(20ml 10秒間注水)を行った.1),2)は暗所開眼下およびフレンッェル眼鏡下,3),4)は暗所開眼下に観察し,眼振最大緩徐相速度,眼振持続時間を比較した.2. 眼振最大緩徐相速度は注水条件,観察条件により異なり,暗所の20°C 5ml 10秒間注水20秒間刺激が最も反応が強く(34.6度/秒),個体間の変動も小さかった.これに対し簡易法による冷温交互試験ではきわめて反応が弱く,温刺激では冷刺激の約2倍の反応が得られたが,8.4度/秒にすぎなかった ...
MIDORIKAWA, CHIKAKO, TAKAHASHI, MASAHIRO, TSUJITA, NAOMI, HOSHIKAWA, HARUKO   +3 more
openaire   +3 more sources

Evaluation of the caloric test by combining 3 response parameters.

, 2000
The slow-phase velocity of nystagmus is one of the most sensitive parameters of vestibular function and is currently the standard for evaluating the caloric test.
Daoui, B., Van Melle, G., Maire, R.
core   +1 more source