Results 21 to 30 of about 14,571 (260)

The effect of souvenaid on functional brain network organisation in patients with mild Alzheimer's disease: a randomised controlled study. [PDF]

PLoS ONE, 2014
Synaptic loss is a major hallmark of Alzheimer's disease (AD). Disturbed organisation of large-scale functional brain networks in AD might reflect synaptic loss and disrupted neuronal communication.
Hanneke de Waal, Cornelis J Stam, Marieke M Lansbergen, Rico L Wieggers, Patrick J G H Kamphuis, Philip Scheltens, Fernando Maestú, Elisabeth C W van Straaten   +7 more
doaj   +1 more source

Homeostasis balance, homeostasis imbalance or distinct motivational processes? Comments on Marks (2015) ‘Homeostatic Theory of Obesity’

Health Psychology Open, 2016
In his article, ‘Homeostatic theory of obesity’, Marks suggested that imbalances in homeostatic processes could explain weight gain and obesity. He proposes that over-consumption of high-caloric, low-nutrient and low satiating foods, combined with a ...
Luc G Pelletier, Camille Guertin, J Paige Pope, Meredith Rocchi   +3 more
doaj   +1 more source

A General Life History Theory for Effects of Caloric Restriction on Health Maintenance [PDF]

BMC Systems Biology, 2011
Caloric restriction (CR) has been shown to keep organisms in a relatively youthful and healthy state compared to ad libitum fed counterparts, as well as to extend the lifespan of a diverse set of organisms. Several attempts have been made to understand the underlying mechanisms from the viewpoint of energy tradeoffs in organisms' life histories ...
Hou, Chen, Bolt, Kendra, Bergman, Aviv
openaire   +2 more sources

Relations of change in fruit and vegetable intake with overall energy reduction and physical activity with weight change: Assessing theory-based psychosocial mediators

Journal of Sport and Health Science, 2019
Background: Increased physical activity and fruit and vegetable (FV) intake are typically suggested to counter obesity. Sustained behavior change in those areas has, however, been poor, possibly because of a lack of understanding of the effects of ...
James J. Annesi
doaj   +1 more source

Game-theoretical description of the go-or-grow dichotomy in tumor development for various settings and parameter constellations

Scientific Reports, 2023
A medically important feature of several types of tumors is their ability to “decide” between staying at a primary site in the body or leaving it and forming metastases. The present theoretical study aims to provide a better understanding of the ultimate
Shalu Dwivedi, Christina Glock, Sebastian Germerodt, Heiko Stark, Stefan Schuster   +4 more
doaj   +1 more source

Head circumference as an epigenetic risk factor for maternal nutrition

Frontiers in Nutrition, 2022
Nutrition indicators for malnutrition can be screened by many signs such as stunting, underweight or obesity, muscle wasting, and low caloric and nutrients intake. Those deficiencies are also associated with low socioeconomic status.
Maria J. Miele, Renato T. Souza, Iracema M. Calderon, Francisco E. Feitosa, Debora F. Leite, Debora F. Leite, Edilberto A. Rocha Filho, Janete Vettorazzi, Jussara Mayrink, Karayna G. Fernandes, Karayna G. Fernandes, Matias C. Vieira, Matias C. Vieira, Rodolfo C. Pacagnella, Jose G. Cecatti, Preterm SAMBA study group   +15 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Understanding the Multifaceted Process of Aging: Theories, Mechanisms, and Implications for Treatment

Al-SalamJournal for Medical Science
The aging process is a multifaceted biological phenomenon characterized by alterations at the molecular, cellular, and organ levels that culminate in a gradual, unavoidable, and unavoidable reduction in the body's capacity to react suitably to internal ...
Omar M. Ameen, Ghada A. Taqa
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Impaired maturation of resting-state connectivity in anorexia nervosa from adolescence to adulthood: differential mechanisms of consummatory vs. anticipatory responses through a symptom provocation paradigm

Frontiers in Behavioral Neuroscience
This functional magnetic resonance imaging (fMRI) study examined resting-state (RS) connectivity in adolescent and adult patients with anorexia nervosa (AN) using symptom provocation paradigms.
Andrea Mendez-Torrijos, Mageshwar Selvakumar, Silke Kreitz, Silke Kreitz, Julie Roesch, Arnd Dörfler, Georgios Paslakis, Johannes Krehbiel, Sabine Steins-Löber, Oliver Kratz, Stefanie Horndasch, Andreas Hess, Andreas Hess, Andreas Hess   +13 more
doaj   +1 more source